Georgotas A, McCue R E, Cooper T B
Depression Studies Program, New York University School of Medicine, New York.
Arch Gen Psychiatry. 1989 Sep;46(9):783-6. doi: 10.1001/archpsyc.1989.01810090025004.
Fifty-one elderly depressed outpatients who had responded to antidepressants and completed continuation therapy were observed under double-blind conditions for 1 year. Twenty-three had been switched to placebo, while 13 and 15 took nortriptyline hydrochloride and phenelzine sulfate, respectively. Patients administered phenelzine did significantly better with 13.3% recurrences than patients administered either nortriptyline (53.8% recurrences) or placebo (65.2% recurrences). In addition, patients who had higher Hamilton scores and who had an earlier age of onset of the first depressive episode were significantly more likely to have recurrences.
51名对抗抑郁药有反应并完成持续治疗的老年抑郁症门诊患者在双盲条件下观察了1年。23名患者被换用安慰剂，而13名和15名患者分别服用盐酸去甲替林和硫酸苯乙肼。服用苯乙肼的患者复发率为13.3%，明显低于服用去甲替林（复发率53.8%）或安慰剂（复发率65.2%）的患者。此外，汉密尔顿评分较高且首次抑郁发作发病年龄较早的患者复发的可能性明显更大。
