Georgotas A, McCue R E, Friedman E, Cooper T B
Department of Psychiatry, New York University School of Medicine, NY 10016.
Br J Psychiatry. 1987 Jul;151:102-6. doi: 10.1192/bjp.151.1.102.
The effects of nortriptyline, phenelzine, and placebo on 13 symptoms of depression were compared in 75 patients, aged 55 or over, who were suffering from major depression. Nortriptyline and phenelzine were more effective than placebo in treating depression mood, guilt feelings, suicidal ideation, agitation, anxiety, loss of energy, and a.m. diurnal variation of mood. Nortriptyline was better than phenelzine or placebo in improving middle/late insomnia. Most of the symptoms did not show significant improvement until the fourth week of treatment.
在75名年龄在55岁及以上的重度抑郁症患者中，比较了去甲替林、苯乙肼和安慰剂对13种抑郁症状的影响。在治疗抑郁情绪、内疚感、自杀意念、激动、焦虑、精力丧失和上午情绪日变化方面，去甲替林和苯乙肼比安慰剂更有效。在改善中/晚期失眠方面，去甲替林比苯乙肼或安慰剂更好。大多数症状直到治疗第四周才显示出显著改善。
