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辅助生殖技术时代精索静脉曲张手术的成本效益

Cost-effectiveness of varicocele surgery in the era of assisted reproductive technology.

作者信息

Chiles Kelly A, Schlegel Peter N

机构信息

Department of Urology, Weill Cornell Medical College, New York, USA.

出版信息

Asian J Androl. 2016 Mar-Apr;18(2):259-61. doi: 10.4103/1008-682X.172644.

DOI:10.4103/1008-682X.172644
PMID:26732113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4770496/
Abstract

The advent of innovative techniques for addressing infertility has made for exciting times in the arena of andrology. The success of microTESE for retrieving sperm has enabled azoospermic men to have the opportunity to father biological children when it was previously impossible. The ability to offer a variety of assisted reproductive techniques that includes intracytoplasmic sperm injection has opened the door for couples with male factor infertility who were otherwise untreatable. With the multitude of options available to infertile couples, however, comes an unsurprising degree of controversy regarding what treatments should be offered and when. Complicating the picture is the question of if and when varicocele repair should be undertaken, and the financial implications of the treatment decisions that are made. The infertile couple with varicocele warrants careful consideration. The overall efficacy of varicocele repair as well as cost-effectiveness of repair compared to immediate microTESE in azoospermic men and assisted reproductive technology in men with suboptimal semen parameters will be reviewed.

摘要

用于解决不孕症的创新技术的出现,使得男科学领域迎来了激动人心的时代。显微睾丸精子提取术(microTESE)在获取精子方面的成功,让无精子症男性有机会生育亲生子女,而这在以前是不可能的。能够提供包括胞浆内单精子注射在内的多种辅助生殖技术,为原本无法治疗的男性因素不孕症夫妇打开了大门。然而,对于不孕夫妇有众多选择的情况,在应该提供何种治疗以及何时提供治疗方面出现了程度不出人意料的争议。精索静脉曲张修复手术是否应该进行以及何时进行的问题,以及所做治疗决策的财务影响,使情况变得更加复杂。患有精索静脉曲张的不孕夫妇值得仔细考虑。本文将综述精索静脉曲张修复术的总体疗效,以及与无精子症男性立即进行显微睾丸精子提取术和精液参数欠佳男性采用辅助生殖技术相比,修复术的成本效益。

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本文引用的文献

1
Spontaneous pregnancy rates in Chinese men undergoing microsurgical subinguinal varicocelectomy and possible preoperative factors affecting the outcomes.中国男性行显微镜下精索内静脉结扎术后的自然妊娠率及可能影响结局的术前因素。
Fertil Steril. 2015 Mar;103(3):635-9. doi: 10.1016/j.fertnstert.2014.12.091. Epub 2015 Jan 23.
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Report on varicocele and infertility: a committee opinion.精索静脉曲张与不育症报告:委员会意见
Fertil Steril. 2014 Dec;102(6):1556-60. doi: 10.1016/j.fertnstert.2014.10.007. Epub 2014 Nov 25.
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The economic implications of multiple pregnancy following ART.辅助生殖技术(ART)后多胎妊娠的经济影响。
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The varicocele.精索静脉曲张。
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Acceptable cost for the patient and society.可接受的患者和社会成本。
Fertil Steril. 2013 Aug;100(2):319-27. doi: 10.1016/j.fertnstert.2013.06.017.
6
The role of varicocele treatment in the management of non-obstructive azoospermia.精索静脉曲张治疗在非梗阻性无精子症治疗中的作用。
Clinics (Sao Paulo). 2013;68 Suppl 1(Suppl 1):89-98. doi: 10.6061/clinics/2013(sup01)10.
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Varicocele repair in the era of modern assisted reproductive techniques.精索静脉曲张修复在现代辅助生殖技术时代。
Curr Opin Urol. 2012 Nov;22(6):517-20. doi: 10.1097/MOU.0b013e328358e191.
8
Contemporary issues in varicocele management.精索静脉曲张治疗的当代问题。
Curr Opin Urol. 2012 Nov;22(6):487-8. doi: 10.1097/MOU.0b013e328359735a.
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Effects of varicocele repair on spontaneous first trimester miscarriage: a randomized clinical trial.精索静脉曲张修复术对孕早期自然流产的影响:一项随机临床试验。
Urol J. 2012 Spring;9(2):505-13.
10
Varicocelectomy does not impact pregnancy outcomes following intracytoplasmic sperm injection procedures.精索静脉曲张切除术对卵胞浆内单精子注射术后的妊娠结局没有影响。
J Androl. 2012 Mar-Apr;33(2):239-43. doi: 10.2164/jandrol.110.011932. Epub 2011 Apr 7.