Greathouse Kelsey M, Palladino Steven P, Dong Chaoling, Helton Eric S, Ubogu Eroboghene E
Department of Neurology, Neuromuscular Immunopathology Research Laboratory, Division of Neuromuscular Disease, The University of Alabama at Birmingham, 1825 University Boulevard, Room 1131, Birmingham, AL, 35294-0017, USA.
J Neuroinflammation. 2016 Jan 6;13:3. doi: 10.1186/s12974-015-0469-3.
Peripheral neuroinflammation is characterized by hematogenous mononuclear leukocyte infiltration into peripheral nerves. Despite significant clinical knowledge, advancements in molecular biology and progress in developing specific drugs for inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis, there are currently no specific therapies that modulate pathogenic peripheral nerve inflammation. Modeling leukocyte trafficking at the blood-nerve barrier using a reliable human in vitro model and potential intravital microscopy techniques in representative animal models guided by human observational data should facilitate the targeted modulation of the complex inflammatory cascade needed to develop safe and efficacious therapeutics for immune-mediated neuropathies and chronic neuropathic pain.
外周神经炎症的特征是血源性单核白细胞浸润到外周神经中。尽管在临床方面有丰富的知识，分子生物学取得了进展，并且在开发针对类风湿性关节炎、炎症性肠病和多发性硬化症等炎症性疾病的特定药物方面也有进展，但目前尚无调节致病性外周神经炎症的特异性疗法。利用可靠的人体体外模型模拟血神经屏障处的白细胞运输，并在人体观察数据的指导下，在代表性动物模型中采用潜在的活体显微镜技术，应该有助于对复杂的炎症级联反应进行靶向调节，从而开发出用于免疫介导性神经病和慢性神经性疼痛的安全有效的治疗方法。
