Lu Jing, Chatterjee Mita, Schmid Hannes, Beck Sandra, Gawaz Meinrad
Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Universität Tübingen, Otfried-Müller-Strasse 10, 72076 Tübingen, Germany.
J Inflamm (Lond). 2016 Jan 5;13:1. doi: 10.1186/s12950-015-0109-9. eCollection 2016.
CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migration, also executes antimicrobial immunity. The identity of the receptor for CXCL14 still remains obscure and therefore the intracellular signaling pathway is not entirely delineated. The present review summarizes the contribution of CXCL14 in these two aspects and discusses the biological mechanisms regulating CXCL14 expression and potential CXCL14 mediated functional implications in a variety of cells.
CXCL14是一种相对较新的趋化因子，是一种具有广泛生物活性的非ELR（谷氨酸-亮氨酸-精氨酸）趋化因子。CXCL14主要有助于调节免疫细胞迁移，也执行抗菌免疫。CXCL14受体的身份仍然不明，因此细胞内信号通路尚未完全阐明。本综述总结了CXCL14在这两个方面的作用，并讨论了调节CXCL14表达的生物学机制以及CXCL14在多种细胞中介导的潜在功能意义。
