de Araújo Lilhian Alves, Mrué Fátima, Neves Roberpaulo Anacleto, Alves Maxley Martins, da Silva-Júnior Nelson Jorge, Silva Marcelo Seixo de Brito, de Melo-Reis Paulo Roberto
Catholic University of Goiás.
Department of Veterinary Medicine, Veterinary School, Goiânia, GO, Brazil.
Arq Bras Cir Dig. 2015 Nov-Dec;28(4):243-6. doi: 10.1590/S0102-6720201500040006.
The use of plants of the family Euphorbiaceae, particularly Euphorbia tirucalli (avelós) has been popularly widespread for treating a variety of diseases of infectious, tumoral, and inflammatory.
To demonstrated antimicrobial and immunomodulatory effects of these extracts, evaluating the effect of a topical treatment with an aqueous solution of avelós latex on the survival and on intestinal adhesions in rats with experimental peritonitis.
Peritonitis was induced in 24 Wistar rats, that were randomized into four groups of six as follows: (1) Control group (n=6), no treatment; (2) Antibiotic group (n=6), treatment with a single intramuscular dose of antibiotic Unasyn; (3) Saline group (n=6), the abdominal cavity was washed with 0.9% saline; and (4) E.tirucalli group (n=6), the abdominal cavity was washed with E. tirucalli at a concentration of 12 mg/ml. The animals that died were necropsied, and the time of death was recorded. The survivors were killed on postoperative day 11, and necropsy was subsequently performed for evaluation of the intestinal adhesions.
Significant differences were observed in the control and antibiotic groups (p<0.01) with respect to the survival hours when compared with the saline and E. tirucalli groups. There was no significant difference (p>0.05) in the survival of animals in the saline andE. tirucalli groups; however, one animal died in the saline group. Necropsy of the animals in the saline and E. tirucalligroups showed strong adhesions resistant to manipulation, between the intestinal loops and abdominal wall. The remaining groups did not show any adhesions.
Topical treatment with E. tirucalli latex stimulated an increased formation of intestinal adhesions and prevented the death of all animals with peritonitis.
大戟科植物的使用，尤其是绿玉树（麻风树），在治疗各种感染性、肿瘤性和炎症性疾病方面已广泛流行。
证明这些提取物的抗菌和免疫调节作用，评估用绿玉树乳胶水溶液进行局部治疗对实验性腹膜炎大鼠存活率和肠粘连的影响。
对24只Wistar大鼠诱发腹膜炎，将其随机分为四组，每组6只，如下：（1）对照组（n = 6），不治疗；（2）抗生素组（n = 6），单次肌肉注射抗生素优立新治疗；（3）生理盐水组（n = 6），用0.9%生理盐水冲洗腹腔；（4）绿玉树组（n = 6），用浓度为12 mg/ml的绿玉树冲洗腹腔。对死亡的动物进行尸检，并记录死亡时间。存活的动物在术后第11天处死，随后进行尸检以评估肠粘连情况。
与生理盐水组和绿玉树组相比，对照组和抗生素组在存活时间上观察到显著差异（p<0.01）。生理盐水组和绿玉树组动物的存活率无显著差异（p>0.05）；然而，生理盐水组有1只动物死亡。生理盐水组和绿玉树组动物的尸检显示肠袢与腹壁之间有强烈的粘连，难以分离。其余组未显示任何粘连。
用绿玉树乳胶进行局部治疗刺激了肠粘连的形成增加，并防止了所有腹膜炎动物的死亡。
