Finkel T H, Cambier J C, Kubo R T, Born W K, Marrack P, Kappler J W
Department of Pediatrics, Howard Hughes Medical Institute, Denver, Colorado 80206.
Cell. 1989 Sep 22;58(6):1047-54. doi: 10.1016/0092-8674(89)90503-5.
During T cell development, the processes of selection and tolerance act on the universe of expressed T cell receptors in the thymic cortex to form the repertoire of mature T cells that will respond to foreign antigen in the context of self-MHC in that animal. We have subdivided the cortical thymocytes into three functionally distinct populations: one population which is antigen-receptor negative, a second population which is antigen-receptor positive and is resistant to deletion by signaling through the antigen receptor, and a third population which is also antigen-receptor positive but is sensitive to deletion. These results have implications for the cellular compartments in which positive and negative selection occur and for the biochemical mechanisms that mediate selection and tolerance.
在T细胞发育过程中，选择和耐受过程作用于胸腺皮质中表达的T细胞受体库，以形成成熟T细胞的库，这些成熟T细胞将在该动物的自身MHC背景下对外源抗原作出反应。我们将皮质胸腺细胞细分为三个功能不同的群体：一个群体是抗原受体阴性，第二个群体是抗原受体阳性且通过抗原受体信号传导对缺失具有抗性，第三个群体也是抗原受体阳性但对缺失敏感。这些结果对发生阳性和阴性选择的细胞区室以及介导选择和耐受的生化机制具有启示意义。
