细胞凋亡及其与自身免疫的关联。 - Suppr

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Apoptosis and its association with autoimmunity.

作者信息

George J, Adler Y, Zhang J, Shoenfeld Y, Youinou P

出版信息

Clin Rheumatol. 1995 Sep;14(5):505-9. doi: 10.1007/BF02208145.

DOI:10.1007/BF02208145

PMID:8549086

Abstract

摘要

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Apoptosis and its association with autoimmunity.细胞凋亡及其与自身免疫的关联。

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Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance.瘢痕疙瘩来源的成纤维细胞对Fas介导的凋亡具有抗性，而自分泌转化生长因子-β1的中和可消除这种抗性。

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A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection.在肝细胞中表达的bcl-2转基因可保护小鼠免于暴发性肝破坏，但不能保护其免于抗Fas抗体注射诱导的快速死亡。

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c-Rel is required for the protection of B cells from antigen receptor-mediated, but not Fas-mediated, apoptosis.c-Rel对于保护B细胞免受抗原受体介导而非Fas介导的细胞凋亡是必需的。

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本文引用的文献

Toward an understanding of the molecular mechanisms of physiological cell death.迈向对生理性细胞死亡分子机制的理解。

Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):786-9. doi: 10.1073/pnas.90.3.786.

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.bcl-x，一种与bcl-2相关的基因，作为凋亡细胞死亡的主要调节因子发挥作用。

Cell. 1993 Aug 27;74(4):597-608. doi: 10.1016/0092-8674(93)90508-n.

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.系统性红斑狼疮患者淋巴细胞的体外凋亡加速。

J Immunol. 1994 Apr 1;152(7):3685-92.

Apoptosis and SLE.细胞凋亡与系统性红斑狼疮

Lupus. 1994 Feb;3(1):1-2. doi: 10.1177/096120339400300101.

Activation interferes with the APO-1 pathway in mature human T cells.激活会干扰成熟人类T细胞中的APO-1通路。

Int Immunol. 1993 Jun;5(6):625-30. doi: 10.1093/intimm/5.6.625.

Apoptosis in SLE--too little or too much?系统性红斑狼疮中的细胞凋亡——过少还是过多？

Clin Exp Rheumatol. 1994 Sep-Oct;12(5):553-9.

Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule.可溶形式的Fas分子对Fas介导的细胞凋亡的保护作用。

Science. 1994 Mar 25;263(5154):1759-62. doi: 10.1126/science.7510905.

The apoptosis-1/Fas protein in human systemic lupus erythematosus.人类系统性红斑狼疮中的凋亡相关因子1/Fas蛋白

J Clin Invest. 1994 Mar;93(3):1029-34. doi: 10.1172/JCI117051.

Cell death: the significance of apoptosis.细胞死亡：细胞凋亡的意义

Int Rev Cytol. 1980;68:251-306. doi: 10.1016/s0074-7696(08)62312-8.

Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.细胞凋亡：一种在组织动力学中具有广泛影响的基本生物学现象。

Br J Cancer. 1972 Aug;26(4):239-57. doi: 10.1038/bjc.1972.33.

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