利用远红光发射的肽核酸-荧光素探针检测活癌细胞中的单点突变
Single point mutation detection in living cancer cells by far-red emitting PNA-FIT probes.
作者信息
Kolevzon N, Hashoul D, Naik S, Rubinstein A, Yavin E
机构信息
The Institute for Drug Research, The School of Pharmacy, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem 91120, Israel.
出版信息
Chem Commun (Camb). 2016 Feb 7;52(11):2405-7. doi: 10.1039/c5cc07502e.
PMID:26735489
Abstract
Peptide nucleic acid bis-quinoline conjugates are reported as attractive far-red emitting probes that detect mutated mRNA in living cells at SNP resolution.
摘要
肽核酸双喹啉共轭物被报道为有吸引力的远红光发射探针，可在单核苷酸多态性分辨率下检测活细胞中的突变mRNA。
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