Shen Ling, You Qi Sheng, Xu Xiaolin, Gao Fei, Zhang Zhibao, Li Bin, Jonas Jost B
*Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China; †Department of Ophthalmology, The 2nd Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China; and ‡Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany.
Retina. 2016 Aug;36(8):1579-85. doi: 10.1097/IAE.0000000000000947.
To assess differences in scleral and choroidal thickness between eyes with secondary high axial myopia caused by congenital glaucoma, eyes with primary high axial myopia, and nonhighly myopic eyes.
The study consisted of 301 Chinese individuals with a mean age of 23.9 ± 22.6 years and mean axial length of 24.8 ± 4.2 mm. It included the "secondary highly myopic group" (SHMG) because of congenital glaucoma (n = 20 eyes; axial length >26.0 mm), the "primary highly myopic group" (PHMG) (n = 73; axial length >26.0 mm), and the remaining nonhighly myopic group (NHMG).
The secondary highly myopic group versus the primary highly myopic group had significantly thinner sclera in the pars plana region (343 ± 71 μm versus 398 ± 83 μm; P = 0.006), whereas scleral thickness in other regions did not differ significantly between both highly myopic groups and was significantly thinner in both highly myopic groups than in the NHMG. Mean total scleral volume did not differ significantly (P > 0.20) between any group (SHMG: 659 ± 106 μm; PHMG: 667 ± 128 μm; NHMG: 626 ± 135 μm). Choroidal thickness was significantly thinner in both highly myopic groups than in the NHMG, with no significant differences between both highly myopic groups. Choroidal volume did not differ significantly (P > 0.40) between any of the groups (SHMG: 43 ± 12 μm; PHMG: 43 ± 13 μm; NHMG: 46 ± 17 μm).
In secondary high axial myopia, the sclera gets thinner anterior and posterior to the equator; whereas in primary high axial myopia, scleral thinning is predominantly found posterior to the equator. Because volume of sclera and choroid did not differ between any group, scleral and choroidal thinning in myopia may be due to a rearrangement of tissue and not due to the new formation of tissue.
评估先天性青光眼所致继发性高度轴性近视患者的眼睛、原发性高度轴性近视患者的眼睛以及非高度近视患者的眼睛在巩膜和脉络膜厚度上的差异。
该研究纳入了301名中国人，平均年龄为23.9±22.6岁，平均眼轴长度为24.8±4.2毫米。研究对象包括因先天性青光眼导致的“继发性高度近视组”（SHMG）（20只眼；眼轴长度>26.0毫米）、“原发性高度近视组”（PHMG）（73只眼；眼轴长度>26.0毫米）以及其余的非高度近视组（NHMG）。
继发性高度近视组与原发性高度近视组相比，在平坦部区域巩膜明显更薄（343±71微米对398±83微米；P=0.006），而在其他区域，两个高度近视组的巩膜厚度无显著差异，且两个高度近视组的巩膜厚度均显著薄于非高度近视组。任何组之间的平均巩膜总体积无显著差异（P>0.20）（SHMG：659±106微米；PHMG：667±128微米；NHMG：626±135微米）。两个高度近视组的脉络膜厚度均显著薄于非高度近视组，两个高度近视组之间无显著差异。任何组之间的脉络膜体积无显著差异（P>0.40）（SHMG：43±12微米；PHMG：43±1
