King Daniel W, King Lynda A, McArdle John J, Shalev Arieh Y, Doron-LaMarca Susan
a Boston University and VA Boston Healthcare System.
b University of Southern California.
Multivariate Behav Res. 2009 Jul 31;44(4):437-64. doi: 10.1080/00273170903103308.
Depression and posttraumatic stress disorder (PTSD) are highly comorbid conditions that may arise following exposure to psychological trauma. This study examined their temporal sequencing and mutual influence using bivariate latent difference score structural equation modeling. Longitudinal data from 182 emergency room patients revealed level of depression symptom severity to be positively associated with changes in PTSD intrusion, avoidance, and hyperarousal over 3 time intervals, beginning shortly after the traumatic event. Higher scores on depression anticipated increases (or worsening) in PTSD symptom severity. The pattern of influence from PTSD symptom severity to change in depression symptom severity simply followed the general trend toward health and well-being. Results are discussed in terms of the dynamic interplay and associated mechanisms of posttrauma depression and PTSD symptom severity.
抑郁症和创伤后应激障碍（PTSD）是高度共病的情况，可能在遭受心理创伤后出现。本研究使用双变量潜在差异得分结构方程模型检查了它们的时间顺序和相互影响。来自182名急诊室患者的纵向数据显示，抑郁症状严重程度与PTSD侵入、回避和过度警觉在3个时间间隔内的变化呈正相关，始于创伤事件后不久。抑郁得分较高预示着PTSD症状严重程度会增加（或恶化）。PTSD症状严重程度对抑郁症状严重程度变化的影响模式只是遵循了朝向健康和幸福的总体趋势。根据创伤后抑郁和PTSD症状严重程度的动态相互作用及相关机制对结果进行了讨论。
