Shahdoost Shahab, Frost Shawn, Dunham Caleb, DeJong Stacey, Barbay Scott, Nudo Randolph, Mohseni Pedram
Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug;2015:2159-62. doi: 10.1109/EMBC.2015.7318817.
Approximately 6 million people in the United States are currently living with paralysis in which 23% of the cases are related to spinal cord injury (SCI). Miniaturized closed-loop neural interfaces have the potential for restoring function and mobility lost to debilitating neural injuries such as SCI by leveraging recent advancements in bioelectronics and a better understanding of the processes that underlie functional and anatomical reorganization in an injured nervous system. This paper describes our current progress toward developing a miniaturized brain-machine-spinal cord interface (BMSI) that converts in real time the neural command signals recorded from the cortical motor regions to electrical stimuli delivered to the spinal cord below the injury level. Using a combination of custom integrated circuit (IC) technology for corticospinal interfacing and field-programmable gate array (FPGA)-based technology for embedded signal processing, we demonstrate proof-of-concept of distinct muscle pattern activation via intraspinal microstimulation (ISMS) controlled in real time by intracortical neural spikes in an anesthetized laboratory rat.
在美国，目前约有600万人患有瘫痪症，其中23%的病例与脊髓损伤（SCI）有关。小型化闭环神经接口有潜力通过利用生物电子学的最新进展以及对受伤神经系统功能和解剖重组背后过程的更好理解，恢复因诸如脊髓损伤等使人衰弱的神经损伤而丧失的功能和行动能力。本文描述了我们在开发一种小型化脑机脊髓接口（BMSI）方面取得的当前进展，该接口可将从皮质运动区域记录的神经指令信号实时转换为传递到损伤水平以下脊髓的电刺激。通过结合用于皮质脊髓接口的定制集成电路（IC）技术和用于嵌入式信号处理的基于现场可编程门阵列（FPGA）的技术，我们在麻醉的实验大鼠中展示了通过皮质内神经尖峰实时控制的脊髓内微刺激（ISMS）实现不同肌肉模式激活的概念验证。
