Kimble J, Austin J
Department of Biochemistry, University of Wisconsin, Madison 53706.
Ciba Found Symp. 1989;144:212-20; discussion 221-6, 290-5. doi: 10.1002/9780470513798.ch12.
During development of the nematode, Caenorhabditis elegans, cell interactions play a significant role in controlling cell fate. Regulatory cells in the somatic gonad control proliferation in the germline and induce formation of the vulva in the hypodermis. In the early embryo, mesodermal cells are induced in a process similar to embryonic induction. In addition, interactions between precursor cells of equivalent developmental potential direct one cell to adopt one fate and the other to adopt a second fate. Two genes have been identified in C. elegans that appear to mediate cell interactions. The glp-1 gene is required for embryonic induction and continued germline proliferation; lin-12 is required for cells of equal developmental potential to adopt different fates. Genetic mosaics indicate that glp-1 may be part of the receiving mechanism in controlling germline proliferation.
在秀丽隐杆线虫的发育过程中，细胞间相互作用在控制细胞命运方面发挥着重要作用。体细胞性腺中的调节细胞控制生殖系中的细胞增殖，并诱导皮下组织中阴门的形成。在早期胚胎中，中胚层细胞通过类似于胚胎诱导的过程被诱导产生。此外，具有同等发育潜能的前体细胞之间的相互作用会引导一个细胞采用一种命运，而另一个细胞采用另一种命运。在秀丽隐杆线虫中已鉴定出两个似乎介导细胞间相互作用的基因。glp - 1基因是胚胎诱导和生殖系持续增殖所必需的；lin - 12基因是具有同等发育潜能的细胞采用不同命运所必需的。遗传嵌合体表明，glp - 1可能是控制生殖系增殖的接收机制的一部分。
