Porta Alberto, Bari Vlasta, Marchi Andrea, De Maria Beatrice, Pistuddi Valeria, Ranucci Marco
Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug;2015:4029-32. doi: 10.1109/EMBC.2015.7319278.
The study demonstrates the ability of an information-theoretic measure, such as the transfer entropy (TE), in detecting the depression of the cardiac baroreflex control and circulatory-cardio mechanical feedforward link during propofol-induced general anesthesia. TE was computed from spontaneous variability of heart period (HP) and systolic arterial pressure (SAP) in patients undergoing coronary artery bypass graft (CABG). TE from SAP to HP and from HP to SAP were evaluated by accounting for the confounding effect of respiration (R) affecting both HP and SAP (i.e. TESAP→HP|R and TEHP→SAP|R respectively). Both TESAP→HP|R and TEHP→SAP|R decreased during general anesthesia, thus suggesting that the strength of the causal relation diminished over both arms of the closed loop HP-SAP control. The squared coherence function between HP and SAP confirmed the decreased HP-SAP coupling during general anesthesia, even though it could not distinguish directionality.
该研究证明了一种信息论度量方法，如转移熵（TE），在检测丙泊酚诱导全身麻醉期间心脏压力反射控制和循环-心脏机械前馈联系受抑制方面的能力。TE是根据冠状动脉旁路移植术（CABG）患者的心率间期（HP）和收缩期动脉压（SAP）的自发变异性计算得出的。通过考虑呼吸（R）对HP和SAP的混杂影响（即分别为TESAP→HP|R和TEHP→SAP|R），评估了从SAP到HP以及从HP到SAP的TE。在全身麻醉期间，TESAP→HP|R和TEHP→SAP|R均降低，这表明闭环HP-SAP控制的双臂因果关系强度减弱。HP和SAP之间的平方相干函数证实了全身麻醉期间HP-SAP耦合降低，尽管它无法区分方向性。
