Bari Vlasta, Ranucci Marco, Marchi Andrea, De Maria Beatrice, Pistuddi Valeria, Porta Alberto
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:2937-2940. doi: 10.1109/EMBC.2016.7591345.
Assigned the universe of knowledge Ω as composed by one target and two exogenous signals, the conditional joint transfer entropy (CJTE), assessing the amount of information jointly transferred from the two sources to the target that can be uniquely linked to one of the two sources, was found useful to study cardiovascular control. We propose the assessment of CJTE from systolic arterial pressure (SAP) and respiration (R) to heart period (HP) conditioned on R (CJTESAP, R→HP|R) along the baroreflex, and from HP and R to SAP conditioned on R (CJTEHP, R→SAP|R) along the feedforward mechanical pathway, in 134 patients undergoing coronary artery bypass graft surgery before (PRE) and after (POST) the induction of general anesthesia. In this group 38 patients developed atrial fibrillation (AF) after surgery, while the remaining individuals did not (noAF, n=96). Both CJTESAP, R→HP|R and CJTEHP, R→SAP|R distinguished AF from noAF individuals in the PRE condition, suggesting an impairment of HP-SAP closed-loop regulation in AF group and the possibility to identify subjects at higher risk to develop post-surgery AF.
将知识全域Ω设定为由一个目标和两个外源性信号组成，条件联合转移熵（CJTE）用于评估从两个源共同转移到目标且可唯一与两个源之一相关联的信息量，已发现其对研究心血管控制有用。我们提议评估在压力反射中以呼吸（R）为条件从收缩期动脉压（SAP）和呼吸（R）到心动周期（HP）的CJTE（CJTESAP，R→HP|R），以及在经前馈机械通路中以R为条件从HP和R到SAP的CJTE（CJTEHP，R→SAP|R），研究对象为134例接受冠状动脉搭桥手术的患者，分别在全身麻醉诱导前（PRE）和诱导后（POST）进行评估。在该组中，38例患者术后发生房颤（AF），其余患者未发生（无房颤组，n = 96）。在PRE条件下，CJTESAP，R→HP|R和CJTEHP，R→SAP|R均能区分AF患者和无房颤患者，提示房颤组HP - SAP闭环调节受损，且有可能识别出术后发生房颤风险较高的患者。
