Chandler James H, Jayne David G, Neville Anne, Culmer Peter R
Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug;2015:8022-5. doi: 10.1109/EMBC.2015.7320254.
Electrochemical and electrical characteristics have the potential to help differentiate between, and assess the health state of, different biological tissues. However, measurement and interpretation of these characteristics is non-trivial. We propose a new DC galvanostatic sensing method for application to laparoscopic cancer surgery. This presents a simple and cost-effective measurement coupled with straightforward data interpretation. This paper describes the electrochemical and electrical theory underpinning the technique. Additionally, we describe a measurement system employing this technique and present an investigation into the feasibility of using it for measuring the resistance of different tissue types. Measurements were performed on ex vivo porcine liver, colon and rectum tissues. Outputs were consistent with theory and showed a significant difference between the resistance of the different tissue types, (one-way ANOVA, F(2, 28) = 1369, p <; 0.01). These findings indicate that this novel technique may be viable as a low cost method for the discrimination and health assessment of tissues in clinical scenarios.
电化学和电学特性有潜力帮助区分不同的生物组织，并评估其健康状态。然而，对这些特性的测量和解读并非易事。我们提出一种新的直流恒电流传感方法，用于腹腔镜癌症手术。该方法提供了一种简单且经济高效的测量方式，同时数据解读直接明了。本文阐述了支撑该技术的电化学和电学理论。此外，我们描述了一个采用该技术的测量系统，并对其用于测量不同组织类型电阻的可行性进行了研究。在离体猪肝脏、结肠和直肠组织上进行了测量。结果与理论相符，且不同组织类型的电阻之间存在显著差异（单因素方差分析，F(2, 28) = 1369，p < 0.01）。这些发现表明，这项新技术作为一种低成本方法，在临床场景中用于组织鉴别和健康评估可能是可行的。
