Timocin Taygun, Ila Hasan Basri, Dordu Tuba, Husunet Mehmet Tahir, Tazehkand Mostafa Norizadeh, Valipour Ebrahim, Topaktas Mehmet
a Department of Biology , Institute of Science, Cukurova University , Adana , Turkey .
b Department of Biology , Faculty of Science and Letters, Cukurova University , Adana , Turkey , and.
Drug Chem Toxicol. 2016;39(3):338-43. doi: 10.3109/01480545.2015.1121276. Epub 2016 Jan 7.
Flurbiprofen is non-steroidal anti-inflammatory drug which is commonly used for its analgesic, antipyretic, and anti-inflammatory effects. The purpose of the study was to explore the genotoxic and cytotoxic effects of flurbiprofen in human cultured lymphocytes by sister chromatid exchange, chromosome aberration, and cytokinesis-blocked micronucleus tests. 10, 20, 30, and 40 μg/mL concentrations of flurbiprofen (solvent is DMSO) were used to treatment of human cultured lymphocytes at two different treatment periods (24 and 48 h). Flurbiprofen had no significant genotoxic effect in any of these tests. But exposing to flurbiprofen for 24 and 48 h led to significant decrease on proliferation index, mitotic index, and nuclear division index (NDI). Also, all decreases were concentration-dependent (except NDI at 24 h treatment period). Consequently, the findings of this research showed that flurbiprofen had cytotoxic effects in human blood lymphocytes.
氟比洛芬是一种非甾体抗炎药，常用于其镇痛、解热和抗炎作用。本研究的目的是通过姐妹染色单体交换、染色体畸变和胞质分裂阻滞微核试验，探讨氟比洛芬对人培养淋巴细胞的遗传毒性和细胞毒性作用。使用10、20、30和40μg/mL浓度的氟比洛芬（溶剂为二甲基亚砜）在两个不同的处理时间（24和48小时）处理人培养淋巴细胞。在任何这些试验中，氟比洛芬均无明显的遗传毒性作用。但暴露于氟比洛芬24和48小时导致增殖指数、有丝分裂指数和核分裂指数（NDI）显著降低。此外，所有降低均呈浓度依赖性（24小时处理期的NDI除外）。因此，本研究结果表明，氟比洛芬对人血淋巴细胞具有细胞毒性作用。
