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阿霉素纳米泡用于兔VX2肝肿瘤的超声检查与靶向化疗联合治疗

Doxorubicin nanobubble for combining ultrasonography and targeted chemotherapy of rabbit with VX2 liver tumor.

作者信息

Meng Mingming, Gao Jie, Wu Chongchong, Zhou Xuan, Zang Xuefeng, Lin Xiangchun, Liu Hong, Wang Canghai, Su Hui, Liu Kuiliang, Wang Yadan, Xue Xinying, Wu Jing

机构信息

The Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, 10 Tieyi Road, Yangfang District, Beijing, 100038, China.

The Department of Pathology, Chinese PLA General Hospital, Beijing, China.

出版信息

Tumour Biol. 2016 Jul;37(7):8673-80. doi: 10.1007/s13277-015-4525-5. Epub 2016 Jan 6.

DOI:10.1007/s13277-015-4525-5
PMID:26738862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4990606/
Abstract

A new class of multifunctional nanobubble using poly(lactic-co-glycolic acid) (PLGA) has been developed as ultrasound imaging contrast agents, doxorubicin carriers, and enhancers of ultrasound-mediated drug delivery. The doxorubicin nanobubble (DOX-NB) wrapping carbon tetrafluoride gas was prepared with double emulsion method. We evaluated the enhanced ultrasonic function of the DOX-NB in vivo; its antitumor function was confirmed. The diameter of the prepared bubble was 500 nm, and the potential was -23 mV. The drug loading and encapsulation efficiency of the bubble were 78.6 and 7.4 %, respectively. Therefore, the DOX-NB greatly enhanced ultrasound imaging in vivo. Ultrasound combined with DOX-NB had significant antitumor effect. Compared with other groups, the tumor growth rate and the proliferation index were the lowest while the survival rate and apoptosis index were the highest.

摘要

一种使用聚乳酸-乙醇酸共聚物（PLGA）的新型多功能纳米气泡已被开发用作超声成像造影剂、阿霉素载体以及超声介导药物递送的增强剂。采用双乳液法制备了包裹四氟化碳气体的阿霉素纳米气泡（DOX-NB）。我们评估了DOX-NB在体内增强超声功能；其抗肿瘤功能得到证实。所制备气泡的直径为500纳米，电位为-23毫伏。气泡的载药量和包封率分别为78.6%和7.4%。因此，DOX-NB极大地增强了体内超声成像。超声联合DOX-NB具有显著的抗肿瘤作用。与其他组相比，肿瘤生长率和增殖指数最低，而存活率和凋亡指数最高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/57dc267ae61e/13277_2015_4525_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/36b0b13a6fc5/13277_2015_4525_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/f7257c41444d/13277_2015_4525_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/1b19eafad642/13277_2015_4525_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/1f8708d26207/13277_2015_4525_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/7a4b31762fb9/13277_2015_4525_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/c62ac21900a8/13277_2015_4525_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/d292f352cf7e/13277_2015_4525_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/034c81335721/13277_2015_4525_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/57dc267ae61e/13277_2015_4525_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/36b0b13a6fc5/13277_2015_4525_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/f7257c41444d/13277_2015_4525_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/1b19eafad642/13277_2015_4525_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/1f8708d26207/13277_2015_4525_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/7a4b31762fb9/13277_2015_4525_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/c62ac21900a8/13277_2015_4525_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/d292f352cf7e/13277_2015_4525_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/034c81335721/13277_2015_4525_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc96/4990606/57dc267ae61e/13277_2015_4525_Fig9_HTML.jpg

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