Cai Xiaowen, Jiang Yuan, Lin Mei, Zhang Jiyong, Guo Huanhuan, Yang Fanwen, Leung Wingnang, Xu Chuanshan
Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Department of Pediatrics, Shenzhen Maternity and Child Health Care Hospital, Shenzhen, China.
Front Pharmacol. 2020 Jan 31;10:1650. doi: 10.3389/fphar.2019.01650. eCollection 2019.
Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.
由于其安全性、对组织的深度穿透性和非侵入性，超声是疾病诊断和治疗中最常用的方法之一。在药物/基因递送系统中，超声在药物/基因的靶向递送和空间释放控制方面显示出许多优势，并吸引了越来越多的关注。微泡是最著名的超声响应性递送材料。最近，纳米气泡、液滴、胶束和纳米脂质体已被开发为该领域的新型载体。在此，我们综述新型超声响应性材料（纳米气泡、液滴、胶束和纳米脂质体）的进展，并讨论超声响应性材料在递送系统中的挑战，以推动超声响应性材料作为递送载体的发展。
