层粘连蛋白在癌症侵袭和转移中的作用。
The role of laminin in cancer invasion and metastasis.
作者信息
Hunt G
机构信息
University of Newcastle upon Tyne, School of Pathological Sciences, Division of Pathology, Royal Victoria Infirmary, UK.
出版信息
Exp Cell Biol. 1989;57(3):165-76. doi: 10.1159/000163521.
Laminin, a basement membrane glycoprotein, has been implicated in a number of stages in tumour invasion and metastasis. In addition to its roles in cell adhesion and migration, laminin may be important in mediating interactions of tumour cells with the immune system and have more subtle roles in controlling metastatic behaviour. Recent work on the prognostic significance of laminin and the possible role of the molecule in antimetastasis therapy will also be discussed.
层粘连蛋白是一种基底膜糖蛋白，在肿瘤侵袭和转移的多个阶段都有涉及。除了在细胞黏附和迁移中发挥作用外，层粘连蛋白在介导肿瘤细胞与免疫系统的相互作用中可能很重要，并且在控制转移行为方面具有更微妙的作用。还将讨论层粘连蛋白的预后意义以及该分子在抗转移治疗中的可能作用的最新研究。
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