内质网/质膜连接处的Orai1和STIM1：在胰腺细胞功能及功能障碍中的作用
Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction.
作者信息
Son Aran, Park Seonghee, Shin Dong Min, Muallem Shmuel
机构信息
Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland;
Department of Physiology, School of Medicine, Ewha Womans University, Seoul, Korea;
出版信息
Am J Physiol Cell Physiol. 2016 Mar 15;310(6):C414-22. doi: 10.1152/ajpcell.00349.2015. Epub 2016 Jan 6.
Abstract
Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca(2+) signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca(2+) signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca(2+) release and Orai1/transient receptor potential canonical-mediated store-dependent Ca(2+) entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca(2+) signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca(2+) signaling in pancreatic acini.
摘要
膜接触位点（MCS）是在内质网（ER）与包括质膜（PM）在内的各种细胞器的膜之间形成的关键连接。信号复合物，包括Ca（2+）信号传导的介质，在MCS内组装，如ER/PM连接。这在极化上皮细胞中最为明显，如胰腺细胞。核心Ca（2+）信号蛋白聚集在顶端极，即肌醇1,4,5-三磷酸介导的Ca（2+）释放和Orai1/瞬时受体电位经典介导的储存依赖性Ca（2+）内流的部位。最近的进展已经确定了在MCS处连接膜的蛋白质以及这些蛋白质在调节生理和病理细胞内信号传导中的作用。本综述讨论了ER/PM连接处Ca（2+）信号传导特征的最新进展以及这些连接与胰腺腺泡中生理和病理Ca（2+）信号传导的关系。
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