Hogan Patrick G
La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Cell Calcium. 2015 Oct;58(4):357-67. doi: 10.1016/j.ceca.2015.07.001. Epub 2015 Jul 17.
The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca(2+) influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca(2+) signalling. This review begins with a brief summary of the STIM-ORAI pathway of store-operated Ca(2+) influx, then turns to the special geometry of the STIM-ORAI microdomain and the expected characteristics of the microdomain Ca(2+) signal. A final section of the review seeks to place the STIM-ORAI microdomain into a broader context of cellular Ca(2+) signalling.
调节蛋白STIM1通过直接的蛋白质-蛋白质相互作用控制Ca(2+)通道ORAI1的门控。由于STIM1锚定在内质网（ER）膜中，而ORAI1位于质膜中，因此STIM-ORAI途径仅在两个膜紧密相邻的位置支持Ca(2+)内流，有效地划定了一个Ca(2+)信号传导的微区。本文首先简要概述了储存性Ca(2+)内流的STIM-ORAI途径，然后转向STIM-ORAI微区的特殊几何结构以及微区Ca(2+)信号的预期特征。本文的最后一部分试图将STIM-ORAI微区置于细胞Ca(2+)信号传导的更广泛背景中。
