基质相互作用分子1-钙释放激活钙通道蛋白1微结构域
The STIM1-ORAI1 microdomain.
作者信息
Hogan Patrick G
机构信息
La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
出版信息
Cell Calcium. 2015 Oct;58(4):357-67. doi: 10.1016/j.ceca.2015.07.001. Epub 2015 Jul 17.
Abstract
The regulatory protein STIM1 controls gating of the Ca(2+) channel ORAI1 by a direct protein-protein interaction. Because STIM1 is anchored in the ER membrane and ORAI1 is in the plasma membrane, the STIM-ORAI pathway can support Ca(2+) influx only where the two membranes come into close apposition, effectively demarcating a microdomain for Ca(2+) signalling. This review begins with a brief summary of the STIM-ORAI pathway of store-operated Ca(2+) influx, then turns to the special geometry of the STIM-ORAI microdomain and the expected characteristics of the microdomain Ca(2+) signal. A final section of the review seeks to place the STIM-ORAI microdomain into a broader context of cellular Ca(2+) signalling.
摘要
调节蛋白STIM1通过直接的蛋白质-蛋白质相互作用控制Ca(2+)通道ORAI1的门控。由于STIM1锚定在内质网（ER）膜中，而ORAI1位于质膜中，因此STIM-ORAI途径仅在两个膜紧密相邻的位置支持Ca(2+)内流，有效地划定了一个Ca(2+)信号传导的微区。本文首先简要概述了储存性Ca(2+)内流的STIM-ORAI途径，然后转向STIM-ORAI微区的特殊几何结构以及微区Ca(2+)信号的预期特征。本文的最后一部分试图将STIM-ORAI微区置于细胞Ca(2+)信号传导的更广泛背景中。
相似文献
1
The STIM1-ORAI1 microdomain.基质相互作用分子1-钙释放激活钙通道蛋白1微结构域
Cell Calcium. 2015 Oct;58(4):357-67. doi: 10.1016/j.ceca.2015.07.001. Epub 2015 Jul 17.
2
The STIM/Orai coupling machinery.STIM/Orai偶联机制。
Channels (Austin). 2008 Jul-Aug;2(4):261-8. doi: 10.4161/chan.2.4.6705. Epub 2008 Jul 21.
3
The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions.储存式钙离子内流的基本单位：内质网-质膜连接处STIM1对CRAC通道的局部激活。
J Cell Biol. 2006 Sep 11;174(6):815-25. doi: 10.1083/jcb.200604015.
4
Privileged coupling between Ca(2+) entry through plasma membrane store-operated Ca(2+) channels and the endoplasmic reticulum Ca(2+) pump.通过质膜钙库操纵型钙通道的钙离子内流与内质网钙离子泵的特权偶联。
Mol Cell Endocrinol. 2012 Apr 28;353(1-2):37-44. doi: 10.1016/j.mce.2011.08.021. Epub 2011 Aug 24.
5
TMEM110 regulates the maintenance and remodeling of mammalian ER-plasma membrane junctions competent for STIM-ORAI signaling.跨膜蛋白110（TMEM110）调控哺乳动物内质网-质膜连接的维持与重塑，该连接对于基质相互作用分子（STIM）-钙释放激活钙通道蛋白（ORAI）信号传导具有活性。
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7083-92. doi: 10.1073/pnas.1521924112. Epub 2015 Dec 7.
6
The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca Entry.STIM-Orai信号通路：储存式钙内流激活过程中STIM与Orai之间的构象偶联
Adv Exp Med Biol. 2017;993:83-98. doi: 10.1007/978-3-319-57732-6_5.
7
Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry.储存式钙离子内流过程中STIM1和Orai1的纳米级模式形成
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5533-42. doi: 10.1073/pnas.1515606112. Epub 2015 Sep 8.
8
Store-operated calcium entry: Mechanisms and modulation.储存式钙内流：机制与调节
Biochem Biophys Res Commun. 2015 Apr 24;460(1):40-9. doi: 10.1016/j.bbrc.2015.02.110.
9
STIM1 activation of Orai1.STIM1 激活 Orai1。
Cell Calcium. 2019 Jan;77:29-38. doi: 10.1016/j.ceca.2018.11.009. Epub 2018 Nov 30.
10
Numbers count: How STIM and Orai stoichiometry affect store-operated calcium entry.数字说话：STIM 和 Orai 计量如何影响钙库操纵性钙内流。
Cell Calcium. 2019 May;79:35-43. doi: 10.1016/j.ceca.2019.02.002. Epub 2019 Feb 12.
引用本文的文献
1
Computational insights in cell physiology.细胞生理学中的计算见解。
Front Syst Biol. 2024 Mar 13;4:1335885. doi: 10.3389/fsysb.2024.1335885. eCollection 2024.
2
CRAC channel activity pulsates during cytosolic Ca oscillations.在胞质钙振荡期间，CRAC通道活性呈脉动变化。
J Biol Chem. 2025 Apr 23;301(6):108519. doi: 10.1016/j.jbc.2025.108519.
3
Exploring the Role of Gut Microbiota and Probiotics in Acute Pancreatitis: A Comprehensive Review.探索肠道微生物群和益生菌在急性胰腺炎中的作用：综述
Int J Mol Sci. 2025 Apr 6;26(7):3433. doi: 10.3390/ijms26073433.
4
Remodeling of ER Membrane Contact Sites During Cell Division.细胞分裂过程中内质网（ER）膜接触位点的重塑
Contact (Thousand Oaks). 2025 Jan 29;8:25152564241309207. doi: 10.1177/25152564241309207. eCollection 2025 Jan-Dec.
5
The Molecular Biology of Placental Transport of Calcium to the Human Foetus.钙向人类胎儿胎盘转运的分子生物学
Int J Mol Sci. 2025 Jan 4;26(1):383. doi: 10.3390/ijms26010383.
6
A bibliometric and visualization analysis of entosis research from 2007 to 2024.2007年至2024年细胞内吞研究的文献计量与可视化分析
Front Oncol. 2024 Oct 28;14:1424100. doi: 10.3389/fonc.2024.1424100. eCollection 2024.
7
Ca2+ tunneling architecture and function are important for secretion.钙离子通道结构与功能对于分泌非常重要。
J Cell Biol. 2025 Jan 6;224(1). doi: 10.1083/jcb.202402107. Epub 2024 Nov 5.
8
Single-nucleus RNA sequencing reveals cell types, genes, and regulatory factors influencing melanogenesis in the breast muscle of Xuefeng black-bone chicken.单核RNA测序揭示了影响雪峰乌鸡胸肌黑色素生成的细胞类型、基因和调控因子。
Poult Sci. 2024 Dec;103(12):104259. doi: 10.1016/j.psj.2024.104259. Epub 2024 Aug 27.
9
Phospholipid scrambling induced by an ion channel/metabolite transporter complex.由离子通道/代谢物转运体复合物诱导的磷脂 scrambling。
Nat Commun. 2024 Aug 31;15(1):7566. doi: 10.1038/s41467-024-51939-w.
10
The bioelectric mechanisms of local calcium dynamics in cancer cell proliferation: an extension of the A549 cell model.癌细胞增殖中局部钙动力学的生物电机制：A549细胞模型的扩展
Front Mol Biosci. 2024 May 6;11:1394398. doi: 10.3389/fmolb.2024.1394398. eCollection 2024.
本文引用的文献
1
Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum-plasma membrane contact sites.延伸突触结合蛋白介导的内质网-质膜接触位点的三维结构
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2004-13. doi: 10.1073/pnas.1503191112. Epub 2015 Mar 18.
2
Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating.在储存耗竭期间，PI(4,5)P2含量低和PI(4,5)P2含量高的微结构域之间的易位决定了STIM1的构象和Orai1的门控。
Nat Commun. 2014 Dec 17;5:5843. doi: 10.1038/ncomms6843.
3
STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel.基质相互作用分子1（STIM1）触发了钙离子释放激活的钙离子通道1（ORAI1）通道胞外侧口处的门控重排。
Nat Commun. 2014 Oct 9;5:5164. doi: 10.1038/ncomms6164.
4
Structural and functional mechanisms of CRAC channel regulation.CRAC通道调控的结构与功能机制。
J Mol Biol. 2015 Jan 16;427(1):77-93. doi: 10.1016/j.jmb.2014.09.021. Epub 2014 Oct 2.
5
Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions.内质网-质膜连接处STIM1和Orai1扩散与捕获的单分子分析。
Mol Biol Cell. 2014 Nov 5;25(22):3672-85. doi: 10.1091/mbc.E14-06-1107. Epub 2014 Jul 23.
6
Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.膜信号复合物的动态组装使Orai1能够选择性激活NFAT。
Curr Biol. 2014 Jun 16;24(12):1361-1368. doi: 10.1016/j.cub.2014.04.046. Epub 2014 Jun 5.
7
Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.脂结合延伸突触结合蛋白的结构表明其在脂转移中的作用。
Nature. 2014 Jun 26;510(7506):552-5. doi: 10.1038/nature13269.
8
Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue.Orai1 依赖性钙内流促进骨骼肌生长并限制疲劳。
Nat Commun. 2013;4:2805. doi: 10.1038/ncomms3805.
9
Feedback regulation of receptor-induced Ca2+ signaling mediated by E-Syt1 and Nir2 at endoplasmic reticulum-plasma membrane junctions.内质网-质膜连接部的 E-Syt1 和 Nir2 介导的受体内化诱导的 Ca2+信号反馈调节。
Cell Rep. 2013 Nov 14;5(3):813-25. doi: 10.1016/j.celrep.2013.09.038. Epub 2013 Oct 31.
10
Oligomerization and Ca2+/calmodulin control binding of the ER Ca2+-sensors STIM1 and STIM2 to plasma membrane lipids.寡聚化和 Ca2+/钙调蛋白控制内质网 Ca2+传感器 STIM1 和 STIM2 与质膜脂质的结合。
Biosci Rep. 2013 Oct 31;33(5):e00077. doi: 10.1042/BSR20130089.
Zotero 插件