Das Shoubhik, Bobbink Felix D, Bulut Safak, Soudani Mylène, Dyson Paul J
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Chem Commun (Camb). 2016 Feb 11;52(12):2497-500. doi: 10.1039/c5cc08741d. Epub 2016 Jan 7.
The catalytic N-formylation and N-methylation of amines using CO2 as the carbon source represents a facile and sustainable approach for the synthesis of pharmaceuticals and natural products. Herein, we describe highly effective and inexpensive thiazolium carbene-based catalysts derived from vitamin B1 for the N-formylation and N-methylation of amines, using polymethylhydrosiloxane (PMHS) as a reducing agent, which operate under ambient conditions.
使用二氧化碳作为碳源对胺进行催化甲酰化和N-甲基化，是一种用于合成药物和天然产物的简便且可持续的方法。在此，我们描述了一种由维生素B1衍生的高效且廉价的噻唑鎓卡宾基催化剂，用于胺的N-甲酰化和N-甲基化反应，该反应以聚甲基氢硅氧烷（PMHS）作为还原剂，在环境条件下进行。
