Zhang Zihou, Beitzel Dylan, Majd Hessam, Mutluay Mustafa, Tezvergil-Mutluay Arzu, Tay Franklin R, Pashley David H, Arola Dwayne
Department of Mechanical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA.
Adhesive Dentistry Research Group, Department of Cariology, Institute of Dentistry, University of Turku, Turku, Finland.
Dent Mater. 2016 Feb;32(2):211-22. doi: 10.1016/j.dental.2015.11.024. Epub 2015 Dec 29.
Recent studies have shown that ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) inactivates endogenous dentin proteases, thereby preventing collagen degradation and improving the durability of adhesive bonds to dentin. Bond durability is routinely assessed by monotonic microtensile testing, which does not consider the cyclic nature of mastication.
To characterize the effect of an EDC pretreatment on the fatigue crack growth behavior of resin-dentin bonds.
Bonded interface Compact Tension (CT) specimens were prepared using a three-step etch-and-rinse adhesive and hybrid resin-composite. Adhesive bonding of the treated groups included a 1 min application of an experimental EDC conditioner to the acid-etched dentin. The control groups did not receive EDC treatment. The fatigue crack growth resistance was examined after storage in artificial saliva for 0, 3 and 6 months.
There was no significant difference in the immediate fatigue crack growth resistance of the EDC-treated and control groups at 0 months. However, after the 3 and 6 months storage periods the EDC-treated groups exhibited significantly greater (p≤0.05) fatigue crack growth resistance than the control specimens.
Although the EDC treatment maintained the fatigue crack growth resistance of the dentin bonds through 6 months of storage, additional studies are needed to assess its effectiveness over longer periods and in relation to other cross-linking agents.
最近的研究表明，3-(3-二甲基氨基丙基)碳二亚胺乙酯（EDC）可使内源性牙本质蛋白酶失活，从而防止胶原蛋白降解并提高与牙本质的粘结耐久性。粘结耐久性通常通过单调微拉伸试验进行评估，该试验未考虑咀嚼的循环性质。
表征EDC预处理对树脂-牙本质粘结疲劳裂纹扩展行为的影响。
使用三步酸蚀冲洗粘结剂和混合树脂复合材料制备粘结界面紧凑拉伸（CT）试样。处理组的粘结包括在酸蚀牙本质上施加1分钟的实验性EDC调节剂。对照组未接受EDC处理。在人工唾液中储存0、3和6个月后，检查疲劳裂纹扩展阻力。
在0个月时，EDC处理组和对照组的即时疲劳裂纹扩展阻力没有显著差异。然而，在储存3个月和6个月后，EDC处理组的疲劳裂纹扩展阻力显著高于对照试样（p≤0.05）。
尽管EDC处理在储存6个月期间维持了牙本质粘结的疲劳裂纹扩展阻力，但需要进一步研究以评估其在更长时期以及与其他交联剂相关的有效性。
