Yui Kunio, Imataka George, Kawasaki Yohei
Research Institute of Pervasive Developmental Disorders, Ashiya University, 13-22 Rokurokusocho, Ashiya, 659-8511, Hyogo, Japan.
Med Chem. 2016;12(4):318-27. doi: 10.2174/1573406412666160107113725.
Autism spectrum disorders (ASD) may be attributed to altered composition of polyunsaturated fatty acids. We examined the relationships between the plasma ratios of docosahexaenoic acid (DHA)/arachidonic acid (AA) and eicosapentaenoic acid (EPA)/AA, and biomarkers of AA-related signaling mediators, i.e., ceruloplasmin, transferrin and superoxide dismutase, with the behavioral symptoms of 30 individuals with ASD (mean age, 13.0 years old) and 20 age- and gender-matched normal controls (mean age, 13.6 years old). Behavioral symptoms were assessed using the Aberrant Behavior Checklists (ABC). The ASD group had significantly higher plasma DHA/AA and EPA/AA ratios, as well as ABC scores, compared to the control group. The plasma ceruloplasmin levels in the ASD group were significantly reduced compared to those in the control group. Multiple linear regression demonstrated that plasma DHA/AA ratio was a fitting model for distinguishing the ASD group from the control group. These findings suggested that increased plasma DHA/AA ratio may be related to lower plasma levels of ceruloplasmin, which may contribute to the pathophysiology of behavioral symptoms in 30 individuals with ASD.
自闭症谱系障碍（ASD）可能归因于多不饱和脂肪酸组成的改变。我们研究了30名自闭症谱系障碍患者（平均年龄13.0岁）和20名年龄及性别匹配的正常对照者（平均年龄13.6岁）的血浆二十二碳六烯酸（DHA）/花生四烯酸（AA）和二十碳五烯酸（EPA）/AA比值与AA相关信号介质的生物标志物，即铜蓝蛋白、转铁蛋白和超氧化物歧化酶，与行为症状之间的关系。使用异常行为检查表（ABC）评估行为症状。与对照组相比，自闭症谱系障碍组的血浆DHA/AA和EPA/AA比值以及ABC评分显著更高。与对照组相比，自闭症谱系障碍组的血浆铜蓝蛋白水平显著降低。多元线性回归表明，血浆DHA/AA比值是区分自闭症谱系障碍组和对照组的合适模型。这些发现表明，血浆DHA/AA比值升高可能与血浆铜蓝蛋白水平降低有关，这可能有助于30名自闭症谱系障碍患者行为症状的病理生理过程。
