Department of Urology, Fujita Medical University School of Medicine, Aichi, 470-1192, Japan.
Department of Pediatrics, Dokkyo Medical University, Tochigi, 321-0293, Japan.
Metab Brain Dis. 2020 Oct;35(7):1101-1108. doi: 10.1007/s11011-020-00585-4. Epub 2020 Jul 8.
The role of malondialdehyde-modified low-density lipoprotein (MDA-LDL), an oxidized LDL, in the pathophysiology of autism spectrum disorder (ASD) is unclear. We studied association between MDA-LDL and behavioral symptoms in 11 individuals with ASD and 7 age -matched normal controls. Behavioral symptoms were assessed using the Aberrant Behavior Checklists (ABC). Because small sample size in this study, three measures were conducted: first, employment of adaptive Lasso for enhancing the accuracy of prediction and interpretability; second, calculation of coefficient of variation for an appropriate selection of plasma variables; and third, selection of good candidates of plasma variables. Plasma levels of MDA-LDL, eicosapentaenoic acid, docosahexaenoic acid (DHA) and DHA/arachidonic acid ratios were significantly higher, while plasma superoxide dismutase (SOD) levels were significantly lower in the ASD group than in the control group. The total ABC scores were significantly higher in the ASD group than in the control group. Multiple linear regression analysis and the adaptive Lasso revealed association of increased plasma DHA levels with the ABC total scores and increased plasma MDA-LDL levels. Such association between DHA and plasma MDA-LDL levels may contribute to behavior in individuals with ASD.
丙二醛修饰的低密度脂蛋白（MDA-LDL）作为一种氧化型 LDL，其在自闭症谱系障碍（ASD）病理生理学中的作用尚不清楚。我们研究了 11 名 ASD 患者和 7 名年龄匹配的正常对照者的 MDA-LDL 与行为症状之间的相关性。采用异常行为检查表（ABC）评估行为症状。由于本研究样本量较小，进行了三项措施：首先，采用适应性套索增强预测的准确性和可解释性；其次，计算变异系数以适当选择血浆变量；第三，选择血浆变量的良好候选者。与对照组相比，ASD 组的 MDA-LDL、二十碳五烯酸、二十二碳六烯酸（DHA）和 DHA/花生四烯酸比值显著升高，而超氧化物歧化酶（SOD）水平显著降低。ASD 组的 ABC 总分明显高于对照组。多元线性回归分析和适应性套索显示，血浆 DHA 水平升高与 ABC 总分升高以及血浆 MDA-LDL 水平升高有关。DHA 与血浆 MDA-LDL 水平之间的这种关联可能有助于 ASD 个体的行为。
