Soto E
Universidad Autónoma de Puebla, ICUAP, Departamento de Ciencias Fisiológicas, Mexico.
Int J Biomed Comput. 1989 Jul;24(2):119-26. doi: 10.1016/0020-7101(89)90014-7.
A computer simulation of membrane potential generation is presented. It allows the user to vary the intra and extracellular concentrations of sodium, potassium and chloride ions (Na+, K+ and Cl-), and determine the membrane potential and the equilibrium potential for each ion. The permeability coefficients for the ionic species considered, and the temperature may also be changed at will. Concentration-potential curves may be obtained at any time. The user may also select a voltage clamp option, which allows him to impose a certain membrane potential value, and study the resulting driving force for each ion. The use of the program in general physiology courses has shown it to be a useful aid for teaching the principles of membrane potential generation.
本文介绍了一种膜电位产生的计算机模拟。它允许用户改变细胞内和细胞外的钠、钾和氯离子（Na+、K+和Cl-）浓度，并确定每种离子的膜电位和平衡电位。所考虑的离子种类的渗透系数以及温度也可以随意改变。随时可以获得浓度-电位曲线。用户还可以选择电压钳选项，这使他能够施加一定的膜电位值，并研究每种离子产生的驱动力。在普通生理学课程中使用该程序已证明它是教授膜电位产生原理的有用辅助工具。
