Çınar Mehmet, Aksoy Rıfat Taner, Güzel Ali İrfan, Tokmak Aytekin, Çandar Tuğba, Taşçı Yasemin
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
J Pediatr Adolesc Gynecol. 2016 Aug;29(4):353-6. doi: 10.1016/j.jpag.2015.12.005. Epub 2015 Dec 29.
To evaluate the correlation between serum cystatin levels and clinical parameters in adolescents with polycystic ovary syndrome (PCOS). DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: This prospective case-control study included 89 adolescents with PCOS. Demographic characteristics and hormonal and biochemical parameters were compared between study (89 patients with PCOS) and control (84 subjects without PCOS) groups. Risk factors recorded were age, body mass index (BMI), waist to hip ratio (WHR), Ferriman-Gallwey score, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein (LDL), high-sensitivity C-reactive protein, cystatin C, follicle stimulating hormone, luteinizing hormone, estradiol, dehydroepiandrosterone sulfate, homeostatic model assessment insulin resistance index, free testosterone, and progesterone levels.
BMI, WHR, Ferriman-Gallwey score, and triglyceride, LDL, total cholesterol, estradiol, dehydroepiandrosterone sulfate, free testosterone, luteinizing hormone, high-sensitivity C-reactive protein, and cystatin C levels, and homeostatic model assessment insulin resistance index scores were significantly higher, and high-density lipoprotein levels were lower in the PCOS patients compared with healthy subjects (P < .05). We also found positive correlations between the cystatin C levels and BMI, WHR, estradiol, high-sensitivity C-reactive protein, and LDL levels in the study group.
The serum cystatin C level is a promising marker for diagnosing adolescent patients with PCOS and suggests an inflammatory etiology for these patients. Further studies with more participants should examine this potential association with inflammation.
评估多囊卵巢综合征（PCOS）青少年血清胱抑素水平与临床参数之间的相关性。
设计、地点、参与者、干预措施及主要观察指标：这项前瞻性病例对照研究纳入了89例PCOS青少年患者。比较了研究组（89例PCOS患者）和对照组（84例非PCOS受试者）的人口统计学特征、激素和生化参数。记录的危险因素包括年龄、体重指数（BMI）、腰臀比（WHR）、费里曼-盖尔韦评分、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白（LDL）、高敏C反应蛋白、胱抑素C、促卵泡激素、促黄体生成素、雌二醇、硫酸脱氢表雄酮、稳态模型评估胰岛素抵抗指数、游离睾酮和孕酮水平。
与健康受试者相比，PCOS患者的BMI、WHR、费里曼-盖尔韦评分、甘油三酯、LDL、总胆固醇、雌二醇、硫酸脱氢表雄酮、游离睾酮、促黄体生成素、高敏C反应蛋白和胱抑素C水平以及稳态模型评估胰岛素抵抗指数得分显著更高，而高密度脂蛋白水平更低（P < 0.05）。我们还发现研究组中胱抑素C水平与BMI、WHR、雌二醇、高敏C反应蛋白和LDL水平之间存在正相关。
血清胱抑素C水平是诊断PCOS青少年患者的一个有前景的标志物，并提示这些患者存在炎症病因。需要更多参与者的进一步研究来检验这种与炎症的潜在关联。
