Amasya University, Faculty of Medicine, Department of Obstetrics and Gynecology, Amasya, Turkey,
Kütahya Health Sciences University, Faculty of Medicine, Department of Gynecology and Obstetrics, Kütahya, Turkey.
Arch Endocrinol Metab. 2022 Jun 3;66(3):372-381. doi: 10.20945/2359-3997000000497. Epub 2022 Jun 2.
Polycystic ovary syndrome (PCOS) begins in adolescence and has cardiovascular and metabolic components in later years. Cystatin C and high-sensitivity C-reactive protein (hs-CRP) levels and neutrophil-lymphocyte and platelet-lymphocyte ratios are associated with metabolic and inflammatory events. Here, we evaluated inflammatory and metabolic parameters in normal and overweight adolescents with PCOS.
This prospective case-control study enrolled 90 adolescents with PCOS and 100 matched by age and BMI healthy adolescents classified as either normal weight (NW) and overweight (OW). Groups were compared based on inflammatory and metabolic parameters (serum cystatin C, hs-CRP, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lipids, fasting blood glucose-insulin (FBG-FI), HOMA-IR levels, waist circumference [WC], and waist-hip ratio [WHR]). The relationship between the parameters were compared and predictive abilities were evaluated.
Cystatin C, hs-CRP, NLR, triglyceride (TG), FBG-FI, HOMA-IR, WC, and WHR were significantly higher in those with PCOS. The NW PCOS group had significantly higher TG, cystatin C, hs-CRP, and NLR versus OW controls. The highest HOMA-IR values were observed in OW PCOS ( < .05). Cystatin C and hs-CRP sensitivity and specificity were significant ( < 0.05). Cystatin C and hs-CRP were positively correlated with other metabolic parameters.
Independent of BMI, inflammatory and metabolic parameters are significantly higher in adolescents with PCOS compared to controls and even worse in those who are also OW. Therefore, adolescents with PCOS should be encouraged to maintain healthy lifestyles and weights to avoid metabolic risks. Hs-CRP and cystatin C could be promising markers to predictive of future metabolic risks.
多囊卵巢综合征（PCOS）始于青春期，在以后的几年中具有心血管和代谢成分。胱抑素 C 和高敏 C 反应蛋白（hs-CRP）水平以及中性粒细胞-淋巴细胞和血小板-淋巴细胞比值与代谢和炎症事件有关。在这里，我们评估了正常和超重青春期 PCOS 患者的炎症和代谢参数。
这项前瞻性病例对照研究纳入了 90 名 PCOS 青少年和 100 名年龄和 BMI 匹配的健康青少年，分为正常体重（NW）和超重（OW）。根据炎症和代谢参数（血清胱抑素 C、hs-CRP、中性粒细胞-淋巴细胞比值（NLR）、血小板-淋巴细胞比值（PLR）、血脂、空腹血糖-胰岛素（FBG-FI）、HOMA-IR 水平、腰围[WC]和腰臀比[WHR]）对两组进行比较。比较了参数之间的关系，并评估了预测能力。
PCOS 患者的胱抑素 C、hs-CRP、NLR、甘油三酯（TG）、FBG-FI、HOMA-IR、WC 和 WHR 均明显升高。与 OW 对照组相比，NW PCOS 组的 TG、胱抑素 C、hs-CRP 和 NLR 明显更高。OW PCOS 组的 HOMA-IR 值最高（<0.05）。胱抑素 C 和 hs-CRP 的敏感性和特异性均具有显著性（<0.05）。胱抑素 C 和 hs-CRP 与其他代谢参数呈正相关。
无论 BMI 如何，与对照组相比，青春期 PCOS 患者的炎症和代谢参数明显更高，而那些同时也是 OW 的患者情况更糟。因此，应鼓励患有 PCOS 的青少年保持健康的生活方式和体重，以避免代谢风险。hs-CRP 和胱抑素 C 可能是预测未来代谢风险的有前途的标志物。
