来自中国一家大学医院的耐喹诺酮鲍曼不动杆菌中blaOXA - 23与armA的共存
Coexistence of blaOXA-23 with armA in quinolone-resistant Acinetobacter baumannii from a Chinese university hospital.
作者信息
Shen Min, Luan Guangxin, Wang Yanhong, Chang Yaowen, Zhang Chi, Yang Jingni, Deng Shanshan, Ling Baodong, Jia Xu
机构信息
Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu Medical College, Chengdu 610500, PR China.
Small Molecule Drugs Key Laboratory of Sichuan Province, Institute of Materia Medica, Chengdu Medical College, Chengdu 610500, PR China.
出版信息
Diagn Microbiol Infect Dis. 2016 Mar;84(3):230-1. doi: 10.1016/j.diagmicrobio.2015.10.009. Epub 2015 Oct 23.
A total of 101 Acinetobacter baumannii isolates were collected to determine the mechanisms of quinolone resistance and investigate the occurrence of carbapenem and high-level aminoglycoside resistance genes among quinolone-resistant strains. Among 77 quinolone-resistant A. baumannii harbored mutations of gyrA and parC, 41 isolates, which belonged to European clone II, had resistance to aminoglycosides and carbapenems due to the expression of armA and acquisition of blaOXA-23. Most of sequence type belonged to clonal complex 92. These results suggested hospital dissemination of multidrug-resistant A. baumannii carrying blaOXA-23, armA, and mutations of quinolone resistance-determining regions in western China.
共收集了101株鲍曼不动杆菌分离株，以确定喹诺酮耐药机制，并调查耐喹诺酮菌株中碳青霉烯和高水平氨基糖苷耐药基因的发生情况。在77株耐喹诺酮鲍曼不动杆菌中，gyrA和parC存在突变，其中41株属于欧洲克隆II，由于armA的表达和blaOXA-23的获得而对氨基糖苷类和碳青霉烯类耐药。大多数序列类型属于克隆复合体92。这些结果表明，在中国西部，携带blaOXA-23、armA和喹诺酮耐药决定区突变的多重耐药鲍曼不动杆菌在医院中传播。
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