Lai De-Hua, Hong Xiao-Kun, Su Bi-Xiu, Liang Chi, Hide Geoff, Zhang Xiaoli, Yu Xinbing, Lun Zhao-Rong
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China.
Trans R Soc Trop Med Hyg. 2016 Jan;110(1):21-7. doi: 10.1093/trstmh/trv100.
The oriental liver fluke, Clonorchis sinensis, a pathogen causing clonorchiasis, is of major socio-economic importance in East Asia, including China, Korea and Vietnam. This parasite is now recognized as a biocarcinogen strongly linked to cholangiocarcinoma in humans. Here, we describe the status of clonorchiasis in China, where it has been estimated that more than 15 million patients are affected. This paper also summarizes the major advances in the field of clonorchiasis research during last decade, including diagnosis techniques, pathogenesis and genome/transcriptome/proteome studies in the last years. We strongly hope that our work can stimulate the governments of the countries or regions where clonorchiasis is endemic to pay more attention to this disease and establish related guidelines to prevent and control it.
华支睾吸虫（Clonorchis sinensis）是引起华支睾吸虫病的病原体，在包括中国、韩国和越南在内的东亚地区具有重大的社会经济意义。这种寄生虫现已被确认为与人类胆管癌密切相关的生物致癌物。在此，我们描述了中国华支睾吸虫病的现状，据估计，中国有超过1500万患者受到影响。本文还总结了过去十年中华支睾吸虫病研究领域的主要进展，包括近年来的诊断技术、发病机制以及基因组/转录组/蛋白质组研究。我们强烈希望我们的工作能够促使华支睾吸虫病流行国家或地区的政府更加关注这种疾病，并制定相关的预防和控制指南。
