Dong Jian-Wei, Cai Le, Li Xue-Jiao, Peng Li, Xing Yun, Mei Rui-Feng, Wang Jia-Peng, Ding Zhong-Tao
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China.
Fitoterapia. 2016 Mar;109:212-6. doi: 10.1016/j.fitote.2015.12.019. Epub 2015 Dec 30.
Two new peroxy fatty acids, thermalic acids A (1) and B (2), together with eight known compounds, (3β)-methyl-3-hydroxy-urs-11-en-28 oate (3), luteolin (4), quercetin (5), 3-methoxyquercetin (6), ophioglonol (7), ophioglonol 4'-O-α-D-glucopyranoside (8), pedunculosumoside B (9), syringol (10), were isolated from the herba of Ophioglossum thermale Kom. The structures of 1 and 2 were identified by HRESIMS, EIMS, 1D and 2D NMR, and electronic circular dichroism (ECD) spectra. Both two acids exhibited potential antibacterial activities against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli. This is the first report of peroxy fatty acids isolated from herbaceous plants of Ophioglossaceae.
从温泉瓶尔小草（Ophioglossum thermale Kom.）的全草中分离得到两种新的过氧脂肪酸——热原酸A（1）和B（2），以及8种已知化合物，分别为（3β）-甲基-3-羟基乌苏-11-烯-28-酸甲酯（3）、木犀草素（4）、槲皮素（5）、3-甲氧基槲皮素（6）、瓶尔小草醇（7）、瓶尔小草醇4'-O-α-D-吡喃葡萄糖苷（8）、长梗菊糖苷B（9）、丁香酚（10）。通过高分辨电喷雾电离质谱（HRESIMS）、电子轰击质谱（EIMS）、一维和二维核磁共振（1D和2D NMR）以及电子圆二色光谱（ECD）对1和2的结构进行了鉴定。这两种酸对金黄色葡萄球菌、枯草芽孢杆菌和大肠杆菌均表现出潜在的抗菌活性。这是首次从瓶尔小草科草本植物中分离得到过氧脂肪酸的报道。
