Sternby Jan, Daugirdas John T
Baxter International, Lund - Sweden.
University of Illinois at Chicago, Chicago, IL - USA.
Int J Artif Organs. 2015 Dec;38(12):632-7. doi: 10.5301/ijao.5000456. Epub 2015 Dec 24.
An empirically-derived equation to estimate hemodialysis treatment variable-volume single-pool Kt/V, where Kt/V = -In(R-GFAC × t) + (4-3.5 × R) × UFV/W, was published in 1993 (1) and quickly became a standard tool for the estimation of dialysis dose. We aim to find a theoretical basis for this equation.
A mathematical derivation is used to find the connection between Kt/V and modeled urea concentrations.
There is a theoretical basis for the empirical structure of the estimating equation, but the estimation of the effect of ultrafiltration on Kt/V can be improved. Finally, we show that the accuracy of the formula may be suboptimal for some extreme dialysis schedules and propose a new equation that is more robust across atypical dialysis prescriptions.
The currently used Kt/V estimating equation has a sound theoretical basis and an improved version is proposed that can maintain accuracy with a broader range of fluid removal.
1993年发表了一个根据经验得出的用于估算血液透析治疗可变容积单池Kt/V的公式，其中Kt/V = -In(R - GFAC × t) + (4 - 3.5 × R) × UFV/W ，该公式迅速成为估算透析剂量的标准工具。我们旨在找出此公式的理论依据。
采用数学推导来找出Kt/V与模拟尿素浓度之间的联系。
估算公式的经验结构有理论依据，但超滤对Kt/V影响的估算可得到改进。最后，我们表明该公式对于某些极端透析方案的准确性可能欠佳，并提出了一个在非典型透析处方中更稳健的新公式。
目前使用的Kt/V估算公式有坚实的理论基础，并提出了一个改进版本，该版本在更广泛的液体清除范围内可保持准确性。
