Tsai Karen C, Danziger-Isakov Lara A, Banach David B
Yale School of Medicine, 800 Howard Avenue, New Haven, CT, USA.
Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 7017, Cincinnati, OH, USA.
Curr Infect Dis Rep. 2016 Jan;18(2):5. doi: 10.1007/s11908-015-0511-8.
Solid organ transplantation is a life-saving procedure that has changed the prognosis for infants and children with end-stage organ disease. Cytomegalovirus (CMV) is one of the most common infections that occur after organ transplantation in pediatric patients, yet the standard of care for CMV prevention remains unclear. We review the literature regarding CMV disease effects, risk factors, diagnostics, prevention strategies, and antiviral treatment in pediatric solid organ transplantation. This discussion focuses on the current prevention strategies: prophylaxis, preemptive, and hybrid therapy, as well as novel strategies that may help better prevent the CMV disease in the pediatric solid organ transplant population.
实体器官移植是一种挽救生命的手术，它改变了患有终末期器官疾病的婴幼儿和儿童的预后。巨细胞病毒（CMV）是儿科患者器官移植后最常见的感染之一，然而CMV预防的护理标准仍不明确。我们回顾了有关儿科实体器官移植中CMV疾病影响、危险因素、诊断、预防策略和抗病毒治疗的文献。本讨论聚焦于当前的预防策略：预防用药、抢先治疗和混合疗法，以及可能有助于更好地预防儿科实体器官移植人群中CMV疾病的新策略。
