Savino Francesco, Viola Serena, Tarasco Valentina, Locatelli Emanuela, Ricagni Alberto, Coppo Paola
Department of Pediatrics and Adolescence - Regina Margherita Children's Hospital, Azienda Ospedaliera Città della Salute e della Scienza di Torino, University of Turin, Piazza Polonia, 94, Torino, 10126, Italy.
Department of Surgery, Dermatology Unit, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
Ital J Pediatr. 2016 Jan 7;42:1. doi: 10.1186/s13052-015-0208-5.
Neonatal Lupus Erythematosus (NLE) is an uncommon autoimmune disease characterized by cutaneous, hepatic, hematological, neurological and cardiac involvement.
Here we report four cases of cutaneous NLE which were referred to our department in the last 10 years and update literature. The newborns presented with different skin, clinical and laboratory features. This underlines the phenotypic variability of NLE. We investigated the passage of maternal antinuclear antibodies (ANA) and extractable nuclear antigen antibodies (ENA) - particularly anti-Ro/SSA, anti-La/SSB and anti-U1 ribonucleoprotein RNP - through the placenta. Despite the positive family background, cutaneous NLE and serological data improved in infants within 4 months without treatment.
The evolution of cutaneous NLE may be the spontaneous regression of lesions within six months without progression to Systemic Lupus Erytehmatosus.
新生儿红斑狼疮（NLE）是一种罕见的自身免疫性疾病，其特征为皮肤、肝脏、血液、神经和心脏受累。
在此我们报告过去10年转诊至我科的4例皮肤型NLE病例并更新文献。这些新生儿表现出不同的皮肤、临床和实验室特征。这突出了NLE的表型变异性。我们研究了母体抗核抗体（ANA）和可提取核抗原抗体（ENA）——特别是抗Ro/SSA、抗La/SSB和抗U1核糖核蛋白RNP——通过胎盘的情况。尽管有阳性家族背景，但未经治疗的婴儿在4个月内皮肤型NLE和血清学数据有所改善。
皮肤型NLE的演变可能是病变在6个月内自发消退，而不会进展为系统性红斑狼疮。
