Borel Frédéric, Delemazure Anne-Sophie, Espitalier Florent, Spiers Andrew, Mirallie Eric, Blanchard Claire
Service de Clinique Chirurgicale Digestive et Endocrinienne, CHU Nantes, 1 place Alexis Ricordeau, 44093, Nantes Cedex 1, France.
Service de Radiologie et Imagerie Médicale, CHU Nantes, Nantes, France.
World J Surg. 2016 Mar;40(3):665-71. doi: 10.1007/s00268-015-3393-x.
This study evaluated the efficiency of transcutaneous laryngeal ultrasonography (TLUS) as an alternative to direct flexible laryngoscopy (DFL) in the early postoperative screening of vocal cord palsy (VCP) after total thyroidectomy, performed for benign and non-extensive malignant disease.
A prospective study was performed on patients who underwent total thyroidectomy between October 2013 and January 2015 at the Nantes University Hospital (France). Patients underwent DFL on postoperative day 1 performed by an otolaryngologist, followed by TLUS performed by a radiologist on postoperative day 1 or 2.
One hundred and three (103) patients were included in this study, 17.5% were male and 82.5% were female, with a mean age of 51 ± 12 years. Nine patients (9.5%) were diagnosed with postoperative VCP using DFL of these cases 2 were not completely resolved at 3 months postoperatively. Three cases of VCP (33%) were diagnosed using TLUS. TLUS had a sensitivity of 33% and a negative predictive value (NPV) of 95% for the diagnosis of postoperative VCP. Vocal cords (VC) were unassessable in 27.2% of patients. Unassessable VC were significantly associated with male gender (p = 0.0001), age (p = 0.0001), weight (p = 0.002), operating time (p = 0.032), postoperative drainage (p = 0.001), and thyroid weight (p = 0.001). Independent risk factors in the multivariate analysis were male gender (p = 0.0001) and age (p = 0.0001). In the group of women under 50-year old, TLUS had a sensitivity of 50% and a NPV of 97.4%.
TLUS sensitivity is insufficient in early postoperative screening of VCP after thyroid surgery. Ultrasonographic VCP diagnosis should be confirmed with DFL.
本研究评估了经皮喉超声检查(TLUS)作为直接软性喉镜检查(DFL)的替代方法,用于对因良性和非广泛性恶性疾病行全甲状腺切除术后声带麻痹(VCP)进行早期术后筛查的有效性。
对2013年10月至2015年1月在法国南特大学医院接受全甲状腺切除术的患者进行了一项前瞻性研究。患者在术后第1天由耳鼻喉科医生进行DFL检查,随后在术后第1天或第2天由放射科医生进行TLUS检查。
本研究共纳入103例患者,其中男性占17.5%,女性占82.5%,平均年龄为51±12岁。通过DFL诊断出9例(9.5%)患者术后发生VCP,其中2例在术后3个月时未完全恢复。通过TLUS诊断出3例VCP(33%)。TLUS诊断术后VCP的敏感性为33%,阴性预测值(NPV)为95%。27.2%的患者声带(VC)无法评估。无法评估的VC与男性性别(p = 0.0001)、年龄(p = 0.0001)、体重(p = 0.002)、手术时间(p = 0.032)、术后引流(p = 0.001)和甲状腺重量(p = 0.001)显著相关。多因素分析中的独立危险因素为男性性别(p = 0.0001)和年龄(p = 0.0001)。在50岁以下女性组中,TLUS的敏感性为50%,NPV为97.4%。
TLUS在甲状腺手术后早期筛查VCP时敏感性不足。超声诊断VCP应通过DFL进行确认。