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细菌性脑膜炎中的宿主-病原体相互作用

Host-pathogen interactions in bacterial meningitis.

作者信息

Doran Kelly S, Fulde Marcus, Gratz Nina, Kim Brandon J, Nau Roland, Prasadarao Nemani, Schubert-Unkmeir Alexandra, Tuomanen Elaine I, Valentin-Weigand Peter

机构信息

Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, CA, USA.

Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, USA.

出版信息

Acta Neuropathol. 2016 Feb;131(2):185-209. doi: 10.1007/s00401-015-1531-z. Epub 2016 Jan 7.

DOI:10.1007/s00401-015-1531-z
PMID:26744349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4713723/
Abstract

Bacterial meningitis is a devastating disease occurring worldwide with up to half of the survivors left with permanent neurological sequelae. Due to intrinsic properties of the meningeal pathogens and the host responses they induce, infection can cause relatively specific lesions and clinical syndromes that result from interference with the function of the affected nervous system tissue. Pathogenesis is based on complex host-pathogen interactions, some of which are specific for certain bacteria, whereas others are shared among different pathogens. In this review, we summarize the recent progress made in understanding the molecular and cellular events involved in these interactions. We focus on selected major pathogens, Streptococcus pneumonia, S. agalactiae (Group B Streptococcus), Neisseria meningitidis, and Escherichia coli K1, and also include a neglected zoonotic pathogen, Streptococcus suis. These neuroinvasive pathogens represent common themes of host-pathogen interactions, such as colonization and invasion of mucosal barriers, survival in the blood stream, entry into the central nervous system by translocation of the blood-brain and blood-cerebrospinal fluid barrier, and induction of meningeal inflammation, affecting pia mater, the arachnoid and subarachnoid spaces.

摘要

细菌性脑膜炎是一种在全球范围内肆虐的疾病，多达半数的幸存者会留下永久性神经后遗症。由于脑膜病原体的内在特性及其引发的宿主反应，感染可导致相对特定的病变和临床综合征，这些病变和综合征是由受影响的神经组织功能受到干扰所致。发病机制基于复杂的宿主-病原体相互作用，其中一些相互作用对某些细菌具有特异性，而其他相互作用则在不同病原体之间共有。在本综述中，我们总结了在理解这些相互作用所涉及的分子和细胞事件方面取得的最新进展。我们重点关注选定的主要病原体，肺炎链球菌、无乳链球菌（B族链球菌）、脑膜炎奈瑟菌和大肠杆菌K1，并且还纳入了一种被忽视的人畜共患病原体——猪链球菌。这些具有神经侵袭性的病原体代表了宿主-病原体相互作用的共同主题，例如黏膜屏障的定植和侵袭、在血流中的存活、通过血脑屏障和血脑脊液屏障的转运进入中枢神经系统，以及诱导脑膜炎症，影响软脑膜、蛛网膜和蛛网膜下腔。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/065324c3c78a/401_2015_1531_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/734555a1b81a/401_2015_1531_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/52046382958e/401_2015_1531_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/0d1502a77ce4/401_2015_1531_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/484452243ff2/401_2015_1531_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/065324c3c78a/401_2015_1531_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/734555a1b81a/401_2015_1531_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/52046382958e/401_2015_1531_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/0d1502a77ce4/401_2015_1531_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21f8/4713723/484452243ff2/401_2015_1531_Fig4_HTML.jpg
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