从一名患有慢性胃炎的墨西哥患者中分离出的幽门螺杆菌7C菌株的全基因组序列
Complete Genome Sequence of Helicobacter pylori Strain 7C Isolated from a Mexican Patient with Chronic Gastritis.
作者信息
Mucito-Varela Eduardo, Castillo-Rojas Gonzalo, Cevallos Miguel A, Lozano Luis, Merino Enrique, López-Leal Gamaliel, López-Vidal Yolanda
机构信息
Departamento de Microbiología y Parasitología, Facultad de Medicina, Programa de Inmunología Molecular Microbiana, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, Distrito Federal, Mexico.
Centro de Ciencias Genómicas, Programa de Genómica Evolutiva, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, Mexico.
出版信息
Genome Announc. 2016 Jan 7;4(1):e01503-15. doi: 10.1128/genomeA.01503-15.
Helicobacter pylori-induced gastritis is a risk factor for developing gastric pathologies. Here, we report the complete genome sequence of a multidrug-resistant H. pylori strain isolated from a chronic gastritis patient in Mexico City, Mexico. Nonvirulent VacA and cag-pathogenicity island (PAI) genotypes were found, but the presence of a potential mobilizable plasmid carrying an IS605 element is of outstanding interest.
幽门螺杆菌引起的胃炎是发生胃部病变的一个危险因素。在此，我们报告了从墨西哥墨西哥城一名慢性胃炎患者分离出的一株耐多药幽门螺杆菌菌株的完整基因组序列。发现了无毒的空泡毒素A（VacA）和细胞毒素相关基因致病岛（cag-PAI）基因型，但携带IS605元件的一个潜在可移动质粒的存在尤为令人关注。
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