Mondoñedo Jarred R, McNeil John S, Amin Samir D, Herrmann Jacob, Simon Brett A, Kaczka David W
Department of Biomedical Engineering, 44 Cummington Mall, Boston University, Boston MA.
Harvard Medical School, Boston, MA; Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA.
Drug Discov Today Dis Models. 2015 Spring;15:43-50. doi: 10.1016/j.ddmod.2014.02.004. Epub 2014 Apr 29.
Status asthmaticus (SA) is a severe, refractory form of asthma that can result in rapid respiratory deterioration and death. Treatment of SA with inhaled anesthetics is a potentially life-saving therapy, but remarkably few data are available about its mechanism of action or optimal administration. In this paper, we will review the clinical use of inhaled anesthetics for treatment of SA, the potential mechanisms by which they dilate constricted airways, and the side effects associated with their administration. We will also introduce the concept of 'targeted' delivery of these agents to the conducting airways, a process which may maximize their therapeutic effects while minimizing associated systemic side effects. Such a delivery regimen has the potential to define a rapidly translatable treatment paradigm for this life-threatening disorder.
哮喘持续状态（SA）是一种严重的、难治性哮喘形式，可导致呼吸迅速恶化甚至死亡。吸入麻醉药治疗SA是一种可能挽救生命的疗法，但关于其作用机制或最佳给药方式的数据却非常少。在本文中，我们将综述吸入麻醉药治疗SA的临床应用、其扩张狭窄气道的潜在机制以及给药相关的副作用。我们还将介绍将这些药物“靶向”递送至传导气道的概念，这一过程可能会在使相关全身副作用最小化的同时最大化其治疗效果。这样一种给药方案有可能为这种危及生命的疾病定义一种可迅速转化的治疗模式。
