Analytical & Testing Center, Sichuan University , Chengdu 610064, China.
Department of Chemistry and Biochemistry, University of California , Santa Cruz, California 95064, United States.
Anal Chem. 2016 Feb 2;88(3):1617-24. doi: 10.1021/acs.analchem.5b03396. Epub 2016 Jan 21.
By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.
通过电沉积和电置换反应，我们开发了一种简便、省时、经济且环保的两步合成路线，以获得用于葡萄糖传感的可控氧化钴/金分级纳米结构电极。通过透射电子显微镜、扫描电子显微镜、拉曼光谱、能谱和 X 射线光电子能谱对纳米材料进行了表征，同时通过循环伏安法和安培响应研究了传感性能。结果表明，这种新型电极对葡萄糖氧化具有优异的电催化性能，具有从 0.2 μM 到 20 mM 的宽双线性范围和基于 3 的信噪比的低检测限 0.1 μM，这主要归因于在具有大表面积和协同电催化活性的氧化钴纳米片表面负载少量具有良好电子导电性的 Au 的能力有利于 Au 和氧化钴对葡萄糖电氧化的协同作用。这种简便、灵敏和选择性的葡萄糖传感器也被证明适用于人血清中葡萄糖的检测。
