Key Laboratory of Automobile Materials, Ministry of Education, and School of Materials Science and Engineering, Jilin University, Changchun 130022, China.
Nat Commun. 2013;4:2169. doi: 10.1038/ncomms3169.
Tremendous demands for electrochemical biosensors with high sensitivity and reliability, fast response and excellent selectivity have stimulated intensive research on developing versatile materials with ultrahigh electrocatalytic activity. Here we report flexible and self-supported microelectrodes with a seamless solid/nanoporous gold/cobalt oxide hybrid structure for electrochemical nonenzymatic glucose biosensors. As a result of synergistic electrocatalytic activity of the gold skeleton and cobalt oxide nanoparticles towards glucose oxidation, amperometric glucose biosensors based on the hybrid microelectrodes exhibit multi-linear detection ranges with ultrahigh sensitivities at a low potential of 0.26 V (versus Ag/AgCl). The sensitivity up to 12.5 mA mM⁻¹ cm⁻² with a short response time of less than 1 s gives rise to ultralow detection limit of 5 nM. The outstanding performance originates from a novel nanoarchitecture in which the cobalt oxide nanoparticles are incorporated into pore channels of the seamless solid/nanoporous Au microwires, providing excellent electronic/ionic conductivity and mass transport for the enhanced electrocatalysis.
电化学生物传感器对高灵敏度和可靠性、快速响应和优异选择性的巨大需求，刺激了人们对具有超高电催化活性的多功能材料的深入研究。在这里，我们报告了具有无缝固/纳米多孔金/氧化钴杂化结构的柔性自支撑微电极，用于电化学无酶葡萄糖生物传感器。由于金骨架和氧化钴纳米粒子对葡萄糖氧化的协同电催化活性，基于混合微电极的安培葡萄糖生物传感器在低电位 0.26 V（相对于 Ag/AgCl）下表现出超宽的多线性检测范围和超高灵敏度。灵敏度高达 12.5 mA mM⁻¹ cm⁻²，响应时间小于 1 s，检测限低至 5 nM。这种优异的性能源于一种新型纳米结构，其中氧化钴纳米粒子被掺入到无缝固/纳米多孔 Au 微米线的孔道中，为增强的电催化提供了出色的电子/离子导电性和质量传输。
