Ingram L, Raimondi S C, Mirro J, Rivera G K, Ragsdale S T, Behm F
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
Leukemia. 1989 Oct;3(10):695-8.
Two patients with acute leukemia were found to have trisomy 11 as the sole chromosomal abnormality. This karyotype has previously been reported in adults with the myelodysplastic syndrome or acute nonlymphocytic leukemia (ANLL). In contrast to previously described cases, both of these patients were young and female. One patient with ANLL had sequential karyotype analysis with trisomy 11 both at presentation and relapse with apparent loss during remission. The other patient had acute lymphoblastic leukemia (ALL) both at presentation and at relapse, although the karyotype was only obtained at relapse. This is the first report of trisomy 11 in ALL.
两名急性白血病患者被发现11号染色体三体是唯一的染色体异常。这种核型此前曾在患有骨髓增生异常综合征或急性非淋巴细胞白血病（ANLL）的成人中报道过。与先前描述的病例不同，这两名患者均为年轻女性。一名ANLL患者在初诊和复发时均进行了11号染色体三体的连续核型分析，缓解期明显缺失。另一名患者初诊和复发时均患有急性淋巴细胞白血病（ALL），不过核型仅在复发时获得。这是ALL中11号染色体三体的首次报道。
