Bigazzi C, Galieni P, Scarinci R, Vivarelli R, Bucalossi A, Biancolini G, Falbo R, Vessichelli F, Dispensa E
Cattedra e Divisione di Ematologia, Siena, Italy.
Haematologica. 1993 May-Jun;78(3):185-6.
A patient with M5b acute nonlymphoblastic leukemia (ANLL) and a 47,XXX del(11) (q23) karyotype is described. Partial remission was obtained after treatment with daunorubicin, arabinosylcytosine and VP-16. Subsequently, two courses of chemotherapy for resistant ANLL were administered without achieving complete remission. Abnormalities of chromosome 11 are typical of M4 and M5 ANLL. X trisomy is one of the most common human aneuploidia; however, correlation with increased incidence of hematological neoplasia has not been described.
本文描述了一名患有M5b型急性非淋巴细胞白血病（ANLL）且核型为47,XXX del(11)(q23)的患者。患者接受柔红霉素、阿糖胞苷和VP-16治疗后获得部分缓解。随后，针对难治性ANLL进行了两个疗程的化疗，但未达到完全缓解。11号染色体异常是M4和M5型ANLL的典型特征。X三体是人类最常见的非整倍体之一；然而，尚未见其与血液系统肿瘤发病率增加相关的报道。
