Charnot-Katsikas Angella, Baewer David, Cook Linda, David Michael Z
Department of Pathology, The University of Chicago Medicine, 5841 S. Maryland Ave., TW003-d, Chicago, IL 60637, USA.
Coppe Healthcare Solutions, W229 N1870 Westwood Dr., Waukesha, WI 53186, USA.
J Clin Virol. 2016 Feb;75:27-32. doi: 10.1016/j.jcv.2015.12.002. Epub 2015 Dec 14.
Mild disease due to human herpesvirus-6 (HHV-6) has been reported in healthy children. Severe disease due to this virus can occur in immunocompromised patients but is rarely reported in previously healthy adults. We report the case of a previously healthy woman who presented with a skin rash, mild upper respiratory symptoms, and abdominal pain and succumbed to fulminant hepatic failure attributed to infection with HHV-6B. HHV-6 may be more commonly associated with fulminant hepatitis in immunocompetent patients than previously thought and should be considered in the differential diagnosis of patients presenting with skin rash, upper respiratory symptoms, and unexplained hepatitis.
健康儿童中曾有人类疱疹病毒6型（HHV - 6）引起轻症疾病的报道。该病毒可在免疫功能低下的患者中引发重症疾病，但在既往健康的成年人中鲜有报道。我们报告了一例既往健康的女性病例，该患者出现皮疹、轻度上呼吸道症状和腹痛，最终因感染HHV - 6B导致暴发性肝衰竭死亡。HHV - 6在免疫功能正常的患者中可能比之前认为的更常与暴发性肝炎相关，对于出现皮疹、上呼吸道症状和不明原因肝炎的患者进行鉴别诊断时应考虑到这一点。
