对来自斯里兰卡唯一一家大学口腔病理学诊断服务机构的896例口腔鳞状细胞癌的描述性研究。
Descriptive study of 896 Oral squamous cell carcinomas from the only University based Oral Pathology Diagnostic Service in Sri Lanka.
作者信息
Jayasooriya Primali Rukmal, Pitakotuwage Thushara Nilmini, Mendis Balapuwaduge Ranjit Rigorbert Nihal, Lombardi Tommaso
机构信息
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.
Laboratory of Oral and Maxillofacial Pathology, Unit of Oral Medicine & Division of Oral and Maxillofacial Surgery, Department of Surgery, University Hospitals of Geneva & University of Geneva, 19, rue Barthelemy-Menn, 1205, Geneva, Switzerland.
出版信息
BMC Oral Health. 2016 Jan 8;16:1. doi: 10.1186/s12903-015-0139-y.
BACKGROUND
The main objective of this study was to describe selected clinico-pathological characteristics of Oral Squamous Cell Carcinoma (OSCC) in Sri-Lanka.
MATERIALS & METHODS: The study sample comprised of eight hundred and ninety six biopsies diagnosed as OSCC. The clinical and histopathological features were analyzed using the Chi-square test.
RESULTS
Of the 896 biopsies, 801 were primary OSCCs, while 95 were recurrent OSCCs. Majority of the patients (78 %) were in the 5(th) to 7(th) decades of life and showed a male predilection. The buccal mucosa was the commonest site of primary OSCC comprising of 43 % of the sample. Of the primary OSCCs, with known TNM stage, 86 % were in stage 3&4 and majority (59 %) of stage 4 tumours showed tumour at one or more excision margins. Of the recurrent OSCC, 46 % developed their recurrences within one year of the excision of the primary tumour.
CONCLUSION
In Sri-Lanka, OSCC is a major problem. Only half the patients had completely excised tumours (with clearance of >5 mm at all excision margins) at operation, and recurrences appeared early. This data should be considered in the future management policy of OSCC in Sri-Lanka.
背景
本研究的主要目的是描述斯里兰卡口腔鳞状细胞癌（OSCC）的某些临床病理特征。
材料与方法
研究样本包括896例被诊断为OSCC的活检病例。使用卡方检验分析临床和组织病理学特征。
结果
在896例活检病例中，801例为原发性OSCC，95例为复发性OSCC。大多数患者（78%）年龄在50至70岁之间，且男性居多。颊黏膜是原发性OSCC最常见的部位，占样本的43%。在已知TNM分期的原发性OSCC中，86%处于3期和4期，4期肿瘤的大多数（59%）在一个或多个切除边缘显示有肿瘤。在复发性OSCC中，46%在原发性肿瘤切除后一年内复发。
结论
在斯里兰卡，OSCC是一个主要问题。只有一半的患者在手术时有完全切除的肿瘤（所有切除边缘的切缘>5毫米），且复发出现较早。在斯里兰卡OSCC未来的管理策略中应考虑这些数据。
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