Kumar Tanoj, Kanade Sanjay Manohar, Singh Rohit, Singh Alisha, Kumar Avanindra, Hiremath Vardar R
Department of Oral Pathology, Patna Dental College and Hospital, Patna, Bihar, India.
Department of Otolaryngology, Rajiv Gandhi Medical College and Chhatrapati Shivaji Maharaj Hospital, Thane, Maharashtra, India.
J Pharm Bioallied Sci. 2020 Aug;12(Suppl 1):S222-S227. doi: 10.4103/jpbs.JPBS_66_20. Epub 2020 Aug 28.
Squamous cell carcinoma (SCC) of maxillofacial region is the most usual form of neoplasia causing malignancies in India and Asian continent. An increased prevalence of mortality rate by cancer of maxillofacial region was observed in various parts of the world.
Our aim was to correlate age and gender with etiopathological factors contributing to oral squamous cell carcinoma (OSCC) in the urban population of Patna in 2 years.
Data were extracted from hospital records. A total of 236 cases of histologically confirmed mild to advance stage of OSCC in either gender of 15-80 years of age range were evaluated.
Out of 236 histopathologically confirmed patients with OSCC, 172 were male and 64 were female. Insignificant difference was found in all age-groups and in all locations. Most common site was found to be buccal mucosa in both genders. Bony invasion was found to be least common. In our study, it was found that habits of chewing areca nuts, nicotine smoke addiction, consumption of alcohol, combination of chewing nuts and nicotine smoke addiction, and combination of alcohol and nicotine smoke addiction are significantly related to the development of OSCC. No significant association was found between histopathological conclusion and gender in all the four groups, and the prevalence was directly proportional to advancement of age.
We concluded that the OSCC do not have any significant relation with the age and gender. The habit of nicotine and areca nut chewing, nicotine smoke addiction, and combination of nicotine smoke addiction and alcohol and chewing nut and nicotine smoke addiction has significant relationship in the development of OSCC.
颌面区域鳞状细胞癌（SCC）是印度和亚洲大陆导致恶性肿瘤最常见的肿瘤形式。在世界不同地区，颌面区域癌症的死亡率普遍上升。
我们的目的是在两年内将年龄和性别与巴特那城市人口中导致口腔鳞状细胞癌（OSCC）的病因病理因素相关联。
数据从医院记录中提取。共评估了236例年龄在15 - 80岁之间、组织学确诊为轻度至晚期OSCC的患者，男女不限。
在236例经组织病理学确诊的OSCC患者中，男性172例，女性64例。在所有年龄组和所有部位均未发现显著差异。发现最常见的部位在男女中均为颊黏膜。骨侵犯被发现是最不常见的。在我们的研究中，发现嚼槟榔、尼古丁成瘾、饮酒、嚼槟榔与尼古丁成瘾的组合以及饮酒与尼古丁成瘾的组合与OSCC的发生显著相关。在所有四组中，组织病理学结论与性别之间均未发现显著关联，且患病率与年龄增长成正比。
我们得出结论，OSCC与年龄和性别没有任何显著关系。尼古丁和槟榔咀嚼习惯、尼古丁成瘾以及尼古丁成瘾与饮酒和嚼槟榔与尼古丁成瘾的组合在OSCC的发生中具有显著关系。
