恐惧学习后情境暴露对小鼠记忆泛化的影响。
Effect of context exposure after fear learning on memory generalization in mice.
作者信息
Fujinaka Ayano, Li Ruoshi, Hayashi Masanobu, Kumar Deependra, Changarathil Gopakumar, Naito Keisuke, Miki Kousuke, Nishiyama Taihei, Lazarus Michael, Sakurai Takeshi, Kee Nohjin, Nakajima Satomi, Wang Szu-Han, Sakaguchi Masanori
机构信息
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Department of Molecular Neuroscience and Integrative Physiology, Faculty of Medicine, Kanazawa University, Ishikawa, Japan.
出版信息
Mol Brain. 2016 Jan 8;9:2. doi: 10.1186/s13041-015-0184-0.
BACKGROUND
The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization.
RESULTS
Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning.
CONCLUSIONS
Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization.
背景
记忆泛化发生的条件尚未得到充分理解。尽管人们认为恐惧记忆泛化是在学习后逐渐形成的，但学习后不久的经历是否会影响泛化尚不清楚。
结果
利用小鼠的情境恐惧条件反射范式，我们发现当小鼠在恐惧学习后不久暴露于熟悉的、未经过条件作用的情境时，恐惧记忆泛化就会发生。
结论
我们的结果表明，情境的熟悉程度及其暴露时间会影响记忆泛化，这增进了我们对泛化机制的理解。
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