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暴露于阳光下身体部位的人类皮肤黑色素瘤中的N-ras突变

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

作者信息

van 't Veer L J, Burgering B M, Versteeg R, Boot A J, Ruiter D J, Osanto S, Schrier P I, Bos J L

机构信息

Department of Clinical Oncology, Leiden University Hospital, The Netherlands.

出版信息

Mol Cell Biol. 1989 Jul;9(7):3114-6. doi: 10.1128/mcb.9.7.3114-3116.1989.

DOI:10.1128/mcb.9.7.3114-3116.1989
PMID:2674680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362784/
Abstract

In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested.

摘要

在37例皮肤黑色素瘤患者中，有7例发现了N-ras基因突变。这7例患者的原发性肿瘤仅位于持续暴露于阳光的身体部位。此外，ras基因突变均发生在已知为紫外线损伤靶点的二嘧啶位点或其附近。有2例原发性肿瘤在ras基因突变方面是双克隆的。提示紫外线照射在诱导这些突变中起积极作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c78/362784/288eb4fcb0ed/molcellb00055-0355-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c78/362784/288eb4fcb0ed/molcellb00055-0355-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c78/362784/288eb4fcb0ed/molcellb00055-0355-a.jpg

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