Violette Nathaniel P, Ledbetter Eric C
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Vet Ophthalmol. 2017 Jan;20(1):27-33. doi: 10.1111/vop.12340. Epub 2016 Jan 8.
To describe clinical features of dogs diagnosed with stromal intracorneal hemorrhage (ICH).
Retrospective case series of 39 dogs (44 eyes) with ICH.
Medical records of dogs evaluated by the Cornell University ophthalmology service were searched to identify animals with a clinical diagnosis of ICH between 2005 and 2014. Signalment and clinical details, including concurrent ocular disease, concurrent systemic disease, diagnostic tests performed, outcome of hemorrhage, presenting client complaint, and treatment, were recorded.
Intracorneal hemorrhage was identified in 44 eyes of 39 dogs. The mean (±standard deviation) age of dogs was 11.5 years (±2.8 years). The Bichon Frise breed and older dogs were statistically over-represented relative to the entire ophthalmology service canine referral population during the same time period. Concurrent ocular disease was present in 40 eyes (91%) and included keratoconjunctivitis sicca, cataracts, and corneal ulcers. Twenty-three dogs (59%) suffered from concurrent systemic disease, most frequently diabetes mellitus, hyperadrenocorticism, hypothyroidism, and systemic hypertension. Less commonly, life-threatening systemic conditions were identified in dogs with ICH including immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, metastatic neoplasia, and sepsis. Intracorneal hemorrhage was found in all corneal locations, and corneal vascularization was present in each affected eye.
Intracorneal hemorrhage is an uncommon condition in dogs that occurs in association with corneal vascularization. The risk of ICH may be increased due to certain ocular and systemic diseases. Although uncommon, ICH may also be an ocular manifestation of severe immune-mediated, infectious, and neoplastic systemic diseases in dogs.
描述被诊断为角膜基质内出血（ICH）的犬只的临床特征。
39只患有ICH的犬（44只眼）的回顾性病例系列。
检索康奈尔大学眼科服务评估的犬只病历，以识别2005年至2014年间临床诊断为ICH的动物。记录品种特征和临床细节，包括并发眼病、并发全身性疾病、进行的诊断测试、出血结果、主人提出的主诉以及治疗情况。
在39只犬的44只眼中发现了角膜内出血。犬只的平均（±标准差）年龄为11.5岁（±2.8岁）。与同一时期整个眼科服务犬转诊群体相比，比熊犬品种和年龄较大的犬只在统计学上占比过高。40只眼（91%）存在并发眼病，包括干眼症、白内障和角膜溃疡。23只犬（59%）患有并发全身性疾病，最常见的是糖尿病、肾上腺皮质功能亢进、甲状腺功能减退和全身性高血压。较少见的是，在患有ICH的犬只中发现了危及生命的全身性疾病，包括免疫介导的溶血性贫血、免疫介导的血小板减少症、转移性肿瘤和败血症。角膜内出血在角膜的所有部位均有发现，且每只患眼均有角膜血管化。
角膜内出血在犬中是一种罕见疾病，与角膜血管化有关。某些眼部和全身性疾病可能会增加ICH的风险。虽然罕见，但ICH也可能是犬严重免疫介导、感染性和肿瘤性全身性疾病的眼部表现。
