Ehala-Aleksejev K, Punab M
Andrology Unit, Tartu University Hospital, Tartu, Estonia.
Andrology. 2016 Jan;4(1):152-9. doi: 10.1111/andr.12136. Epub 2016 Jan 8.
The aim of this study was to investigate the relations of basic semen parameters and reproductive hormones with alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT). In addition, to examine possible interaction between adiposity, alcohol consumption, and liver tests in relation to male reproductive health, standard semen analysis was performed and serum levels of reproductive hormones and liver tests were measured in 245 male partners of pregnant women at a University Hospital Andrology Centres in Estonia. Quartile analysis revealed that after adjustment for covariates GGT was negatively related to sperm concentration and total sperm count. These significant changes appeared from a GGT >35.5 U/L. Next to these changes ALT was not related to sperm parameters. Both enzymes, GGT and ALT, were not related to reproductive hormones. Alcohol consumption was positively related to GGT and in cases with elevated GGT alcohol use was negatively related to sperm concentration and total sperm count. Alcohol consumption was positively related to body mass index (BMI) and waist circumference (WC). Our findings also confirm results of previous studies that BMI and WC are associated positively with ALT and GGT. According to the study, increased GGT activity might represent a possible connection between adiposity, alcohol consumption, and semen quality.
本研究旨在探讨精液基本参数及生殖激素与丙氨酸氨基转移酶（ALT）和γ-谷氨酰转移酶（GGT）之间的关系。此外，为了研究肥胖、饮酒与肝脏检测指标在男性生殖健康方面可能存在的相互作用，在爱沙尼亚一家大学医院男科中心，对245名孕妇的男性伴侣进行了标准精液分析，并检测了生殖激素血清水平和肝脏检测指标。四分位数分析显示，在对协变量进行校正后，GGT与精子浓度和精子总数呈负相关。当GGT>35.5 U/L时出现这些显著变化。除此之外，ALT与精子参数无关。GGT和ALT这两种酶均与生殖激素无关。饮酒与GGT呈正相关，在GGT升高的情况下，饮酒与精子浓度和精子总数呈负相关。饮酒与体重指数（BMI）和腰围（WC）呈正相关。我们的研究结果也证实了先前研究的结果，即BMI和WC与ALT和GGT呈正相关。根据该研究，GGT活性增加可能代表肥胖、饮酒与精液质量之间存在某种联系。
